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Titolo:
Effect of dopexamine on hepatic metabolic activity in patients with septicshock
Autore:
Kiefer, P; Tugtekin, I; Wiedeck, H; Vogt, J; Wachter, U; Bracht, H; Geldner, G; Georgieff, M; Radermacher, P;
Indirizzi:
Univ Ulm Klinikum, Dept Anesthesiol, D-89075 Ulm, Germany Univ Ulm Klinikum Ulm Germany D-89075 Anesthesiol, D-89075 Ulm, Germany
Titolo Testata:
SHOCK
fascicolo: 6, volume: 15, anno: 2001,
pagine: 427 - 431
SICI:
1073-2322(200106)15:6<427:EODOHM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLANCHNIC BLOOD-FLOW; OXYGEN-TRANSPORT; INDUCED INCREASE; CRITICALLY ILL; SEPSIS; DOBUTAMINE; KINETICS; GLUCOSE; BALANCE; FAILURE;
Keywords:
catecholamines; endogenous glucose production; hepato-splanchnic metabolic rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kiefer, P Univ Ulm Klinikum, Dept Anesthesiol, Prittwitzstr 43, D-89075 Ulm, Germany Univ Ulm Klinikum Prittwitzstr 43 Ulm Germany D-89075 , Germany
Citazione:
P. Kiefer et al., "Effect of dopexamine on hepatic metabolic activity in patients with septicshock", SHOCK, 15(6), 2001, pp. 427-431

Abstract

Hepato-splanchnic metabolic activity is seen to be related to regional blood flow and oxygen/substrate availability in patients with sepsis. Catecholamines, which may modulate metabolic activity per se, are common to stabilize hemodynamics. We studied the effect of a dopexamine-induced increase in splanchnic blood flow (Qspl) on regional metabolic rate in 10 patients withseptic shock requiring norepinephrine to maintain mean arterial pressure (>60 mmHg). Splanchnic blood flow was determined using the indocyanine-greenmethod with hepatic venous sampling. We determined the hepato-splanchnic lactate, pyruvate, alanine, and glutamine turnover and the lactate/pyruvate and ketone body ratio as well as the endogenous glucose production (EGP) using the stable isotope approach. Qspl increased from 0.86 (0.79-1.15) to 0.96 (0.92-1.33) L/min/m(2), not influencing any parameter of metabolic activity. We speculate that this finding is due to altered beta -adrenoreceptor-mediated thermogenic effects due to the interplay of different beta -sympathomimetics at the receptor site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:43:00