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Titolo:
A new function for the LH/CG receptor: Transcytosis or hormone across the endothelial barrier in target organs
Autore:
Ghinea, N; Milgrom, E;
Indirizzi:
Hop Bicetre, INSERM, U135, F-94275 Le Kremlin Bicetre, France Hop BicetreLe Kremlin Bicetre France F-94275 Le Kremlin Bicetre, France
Titolo Testata:
SEMINARS IN REPRODUCTIVE MEDICINE
fascicolo: 1, volume: 19, anno: 2001,
pagine: 97 - 101
SICI:
1526-8004(2001)19:1<97:ANFFTL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; LUTROPIN CHORIOGONADOTROPIN RECEPTOR; MESSENGER-RIBONUCLEIC-ACID; EXTRACELLULAR DOMAIN; PULSATILE SECRETION; MEDIATED TRANSPORT; CANCER PREVENTION; PROTEIN HORMONES; MENSTRUAL-CYCLE; BINDING-SITES;
Keywords:
LH/CG receptor; endothelial cells; receptor-mediated transcytosis; lutropin; protein hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ghinea, N Hop Bicetre, INSERM, U135, 3e Niveau,78 Rue Gen Leclerc, F-94275Le Kremlin Bicetre, France Hop Bicetre 3e Niveau,78 Rue Gen Leclerc Le Kremlin Bicetre France F-94275
Citazione:
N. Ghinea e E. Milgrom, "A new function for the LH/CG receptor: Transcytosis or hormone across the endothelial barrier in target organs", SEMIN REP M, 19(1), 2001, pp. 97-101

Abstract

Gonadotropins cross the vascular endothelial barrier to reach their targetorgans. Hormone concentrations in blood are very low and fluctuate rapidlyto give sharp biological effects. Nonspecific transendothelial transport mechanisms are slow and markedly concentration dependent. There is thus a need for specific transendothelial transport mechanisms for these hormones. We will describe a specific transcytosis mechanism involving endothelial lutropin/chorionic gonadotropin (LH/CG) receptors identical to those observed in the target Leydig cells. A new role for the LH/CG receptor as a transcytotic carrier of its ligands in endothelial cells is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:37:05