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Titolo:
Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors
Autore:
Shemesh, M; Mizrachi, D; Gurevich, M; Stram, Y; Shore, LS; Fields, MJ;
Indirizzi:
Kimron Vet Inst, Dept Hormone Res, IL-50250 Bet Dagan, Israel Kimron Vet Inst Bet Dagan Israel IL-50250 es, IL-50250 Bet Dagan, Israel Kimron Vet Inst, Dept Virol, IL-50250 Bet Dagan, Israel Kimron Vet Inst Bet Dagan Israel IL-50250 ol, IL-50250 Bet Dagan, Israel Univ Florida, Dept Anim Sci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Anim Sci, Gainesville, FL 32611 USA
Titolo Testata:
SEMINARS IN REPRODUCTIVE MEDICINE
fascicolo: 1, volume: 19, anno: 2001,
pagine: 87 - 96
SICI:
1526-8004(2001)19:1<87:FIOBMA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; LUTEINIZING-HORMONE RECEPTOR; MESSENGER-RIBONUCLEIC-ACID; INDUCED UP-REGULATION; SMOOTH-MUSCLE CELLS; ESTROUS-CYCLE; BINDING-SITES; PROSTAGLANDIN PRODUCTION; PLASMA-CONCENTRATIONS; LH/HCG RECEPTORS;
Keywords:
myometrium; LH; LH receptors; bovine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Shemesh, M Kimron Vet Inst, Dept Hormone Res, POB 12, IL-50250 Bet Dagan, Israel Kimron Vet Inst POB 12 Bet Dagan Israel IL-50250 Dagan, Israel
Citazione:
M. Shemesh et al., "Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors", SEMIN REP M, 19(1), 2001, pp. 87-96

Abstract

Bovine myometrium and cervix contain luteinizing hormone/human chorionic gonadotropin (LH/hCG) binding sites, LH receptor (LH-R) messenger RNA (mRNA), and LH-R protein. Expression of LH-R is dependent on the stage of the cycle. LH-R expression is high during the luteal phase but weak during the follicular phase. In both myometrium and cervix, LH activates both the adenylate cyclase and phospholipase C pathways, and the effect of LH on both pathways at each stage of the cycle is correlated with the amount of LH-R present in the tissue. Because activation of cyclic AMP (cAMP) is associated withmyometrial quiescence, we suggest that LH activation of uterine cAMP couldserve to keep the uterus quiescent during the luteal phase. On the other hand, in the uterine vein LH-R mRNA and LH-R are maximal during preestrus/estrus as opposed to the luteal phase. In the uterine vein, LH increases the expression of cyclooxygenase and production of both prostaglandin E-2 (PGE(2)) and PCF2 alpha. Because PGF(2 alpha) is the physiological luteolytic signal in the cow, we suggest that this increase in prostaglandin production by the uterine vein is part of the physiological events leading to luteolysis. In addition to uterine LH-R, the bovine cervix at preestrus/estrus has high levels of follicle-stimulating hormone receptor (FSH-R) and its corresponding mRNA. As with LH-R, activation of FSH-R by FSH is associated with activation of a G protein-coupled receptor family that mediates the cAMP andinositol phosphate signaling pathways. Activation of these signaling pathways is associated with an increase in the expression of cyclooxygenase and production of PGE(2). Because expression of the FSH receptor was maximal atthe time of the FSH peak in the blood, we suggest a physiological role forFSH in the cervix relaxation and opening at estrus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 21:58:09