Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A proposed role for hCC in clinical obstetrics
Autore:
Kurtzman, JT; Wilson, H; Rao, CV;
Indirizzi:
Univ Calif Irvine, Irvine Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Orange, CA USA Univ Calif Irvine Orange CA USA , Div Maternal Fetal Med, Orange, CA USA Univ Louisville, Dept Obstet & Gynecol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Gynecol, Louisville, KY 40292 USA
Titolo Testata:
SEMINARS IN REPRODUCTIVE MEDICINE
fascicolo: 1, volume: 19, anno: 2001,
pagine: 63 - 68
SICI:
1526-8004(2001)19:1<63:APRFHI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; LUTEINIZING-HORMONE RECEPTORS; HUMAN MYOMETRIAL CONTRACTIONS; GAP-JUNCTIONS; GENE-EXPRESSION; BINDING-SITES; MOLECULAR-CLONING; FETAL FIBRONECTIN; PRETERM DELIVERY; HUMAN PLACENTA;
Keywords:
hCG; pregnancy; uterine quiescence; preterm labor; tocolytic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Kurtzman, JT 24411 Hlth Ctr Dr,Suite 260, Laguna Hills, CA 92653 USA 24411 Hlth Ctr Dr,Suite 260 Laguna Hills CA USA 92653 53 USA
Citazione:
J.T. Kurtzman et al., "A proposed role for hCC in clinical obstetrics", SEMIN REP M, 19(1), 2001, pp. 63-68

Abstract

The role of human chorionic gonadatropin (hCG) in the maintenance of earlypregnancy is well known. Recent data suggests that hCG may play a role in the maintenance of the later stages of pregnancy as well, by directly and indirectly promoting uterine quiescence. If hCG acts as an endogenous tocolytic in normal pregnancy, then it may be an ideal candidate for therapy of preterm labor as well. We present compelling in vitro as well as in vivo data, which support the role of hCG in the maintenance of normal uterine quiescence. Additionally, we will present in vivo and in vitro data that confirms the ability of hCG to directly promote relaxation of uterine contractions. This review provides a basis for future study of the use of hCG in clinical obstetrics. Given the limited effectiveness of tocolytic therapies available at the time, hCG may provide a promising pharmacological approach to the pervasive problem of preterm labor in human pregnancy. While further work is needed, initial data strongly support this novel use of hCG in clinical obstetrics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:24:33