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Titolo:
Nongonadal LH/hCG receptors in pig: Functional importance and parallels tohuman
Autore:
Ziecik, AJ; Derecka, K; Gawronska, B; Stepien, A; Bodek, G;
Indirizzi:
Polish Acad Sci, Inst Anim Reprod & Food Res, Div Reprod Endocrinol & Pathophysiol, PL-10746 Olsztyn, Poland Polish Acad Sci Olsztyn Poland PL-10746 hysiol, PL-10746 Olsztyn, Poland
Titolo Testata:
SEMINARS IN REPRODUCTIVE MEDICINE
fascicolo: 1, volume: 19, anno: 2001,
pagine: 19 - 30
SICI:
1526-8004(2001)19:1<19:NLRIPF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; LUTEINIZING-HORMONE-RECEPTOR; SMOOTH-MUSCLE CELLS; LUTROPIN-CHORIOGONADOTROPIN RECEPTOR; CYCLASE SIGNALING SYSTEMS; HUMAN FALLOPIAN-TUBES; UTERINE BLOOD-FLOW; NEONATAL RAT OVARY; GENE-EXPRESSION; BREAST-CANCER;
Keywords:
LH/hCG receptor; reproduction; human; pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Ziecik, AJ Polish Acad Sci, Inst Anim Reprod & Food Res, Div Reprod Endocrinol & Pathophysiol, Ul Tuwina 10, PL-10746 Olsztyn, Poland Polish Acad SciUl Tuwina 10 Olsztyn Poland PL-10746 n, Poland
Citazione:
A.J. Ziecik et al., "Nongonadal LH/hCG receptors in pig: Functional importance and parallels tohuman", SEMIN REP M, 19(1), 2001, pp. 19-30

Abstract

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) share a common receptor in gonadal cells; however, the presence of these receptors has also been detected in several nongonadal but reproduction-associated tissues of pig, human, and other species. There are no data about the ontogeny of the human LH/hCG receptor. The expression of the porcine LH receptor gene in the uterus starts about 10 days after the appearance of this gene in gonads. LH/hCG receptors were found in uterus (myometrium, endometrium), oviduct, cervix, fetal membranes, and umbilical cord in humans and pigs. The main role of LH/hCG receptors in myometrium is stimulation of growth and hyperplasia and relaxation of uterine motility. hCG also increases blood flow in the uterine artery. LH and hCG can increase production of prostaglandinsin endometrium, oviduct, and blood vessels. It is suggested that the preovulatory surge of LH plays an important role in controlling oviductal contractions. Human and pig mammary glands also possess LH/hCG receptors through which gonadotropins can affect the metabolism of steroid hormones in this tissue and may play an inhibitory role in mammary carcinogenesis and in the growth of breast tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:51:49