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Titolo:
Corticobasal degeneration
Autore:
Stover, NP; Watts, RL;
Indirizzi:
Emory Univ, Sch Med, Dept Neurol, Movement Disorder Program, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 t Disorder Program, Atlanta, GA 30322 USA Wesley Woods Geriatr Ctr, Atlanta, GA 30322 USA Wesley Woods Geriatr Ctr Atlanta GA USA 30322 Ctr, Atlanta, GA 30322 USA
Titolo Testata:
SEMINARS IN NEUROLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 49 - 58
SICI:
0271-8235(2001)21:1<49:CD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; BASAL GANGLIONIC DEGENERATION; ATYPICAL PARKINSONIAN DISORDERS; MULTIPLE SYSTEM ATROPHY; FLUORODOPA UPTAKE; PICKS-DISEASE; CLINICAL HETEROGENEITY; GLUCOSE-METABOLISM; NATURAL-HISTORY; APRAXIA;
Keywords:
corticobasal degeneration; atypical parkinsonism; neurodegenerative disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Watts, RL Emory Univ, Sch Med, Dept Neurol, Movement Disorder Program, 1639 Pierce Dr,Suite 6000 WMRB, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Suite 6000 WMRB Atlanta GA USA 30322 A
Citazione:
N.P. Stover e R.L. Watts, "Corticobasal degeneration", SEM NEUROL, 21(1), 2001, pp. 49-58

Abstract

Corticobasal degeneration (CBC) is an increasingly recognized neurodegenerative disease with both motor and cognitive dysfunction. The diagnosis is probably underestimated because of the heterogeneity of clinical features, overlap with symptoms: and pathologic findings of other neurodegenerative diseases. The most characteristic initial motor symptoms are akinesia, rigidity, and apraxia. Dystonia and alien limb phenomena are frequently observed. There is often a parkinsonian picture with failure or lack of efficacy of dopaminergic medical therapy. Cognitive decline, prompting the diagnosis ofdementia, may be the most common presentation of CBD that is misdiagnosed. Pathology is characterized by an asymmetric frontoparietal neuronal loss and gliosis with ballooned, achromatic cortical neurons, nigral degeneration, and variable subcortical involvement. Neuroimaging and electrophysiologicstudies may help with the diagnosis but are not specific. Treatment is primarily symptomatic and minimally effective, especially after the first several years of symptoms. CBD should be considered in the differential diagnosis of patients with motor and cognitive dysfunction presenting with cortical and subcortical features. Further studies to elucidate molecular abnormalities and biological markers associated with CBD are needed to improve clinical diagnosis and treatment of patients with this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:36:35