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Titolo:
Pharmacokinetics of reboxetine in healthy volunteers with different ethnicdescents
Autore:
Hendershot, PE; Fleishaker, JC; Lin, KM; Nuccio, ID; Poland, RE;
Indirizzi:
Pharmacia & Upjohn Inc, Clin Pharmacol 2, Kalamazoo, MI 49007 USA Pharmacia & Upjohn Inc Kalamazoo MI USA 49007 2, Kalamazoo, MI 49007 USA Harbor UCLA Res & Educ Inst, Dept Psychiat, Torrance, CA USA Harbor UCLA Res & Educ Inst Torrance CA USA t Psychiat, Torrance, CA USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 155, anno: 2001,
pagine: 148 - 153
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; PLASMA-PROTEIN BINDING; CHINESE; ANTIDEPRESSANT; ENANTIOMERS; CAUCASIANS; DRUGS; PHARMACODYNAMICS; BIOAVAILABILITY; DISPOSITION;
Keywords:
pharmacokinetics; reboxetine; blacks; Asians; ethnicity; race;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fleishaker, JC Pharmacia & Upjohn Inc, Clin Pharmacol 2, 7215-24-205, Kalamazoo, MI 49007USA Pharmacia & Upjohn Inc 7215-24-205 Kalamazoo MI USA 49007 A
Citazione:
P.E. Hendershot et al., "Pharmacokinetics of reboxetine in healthy volunteers with different ethnicdescents", PSYCHOPHAR, 155(2), 2001, pp. 148-153

Abstract

Rationale: Ethnicity can affect the pharmacokinetics and pharmacodynamics of psychopharmacologic drugs. Objectives: Reboxetine disposition differences among Asians, blacks, and Caucasians were examined. Methods: Healthy subjects (12 Asians, 12 blacks, 12 Caucasians) received a single oral dose of one 4-mg reboxetine tablet in an open label, parallel study design. Plasma concentrations of reboxetine enantiomers [R,R(-) reboxetine and predominantly active S,S(+) reboxetine] were quantified using HPLC-MS-MS. Plasma unbound fractions of reboxetine enantiomers were evaluated by equilibrium dialysis. Ethnic group effects on pharmacokinetic parameters were assessed by ANOVA. Results: Mean S,S(+) reboxetine CLPO for blacks was significantly greater, compared to Asians and Caucasians (154+/-82 ml/min, 101+/-19 ml/min and 101+/-18 ml/min, respectively). Mean S,S(+) reboxetine free fractions (fu) were significantly greater for Asians and blacks, compared to Caucasians (3.04+/-1.28%, 2.89+/-0.69%, and 1.99+/-0.58%, respectively). S,S(+) Reboxetine unbound clearance (CLu) was significantly less for Asians, compared to blacks and Caucasians (3742+/-1468 ml/min, 5187+/-2027 ml/min, and 5294+/-1163 ml/min, respectively). S,S(+) Reboxetine mean unbound AUC (AUCu) in these groups were 20.2+/-7.1 ng.h/ml, 14.6+/-5.1 ng.h/ml, and 13.2+/-3.2 ng.h/ml, respectively. AUCu was significantly greater for Asians. CLu and AUCu did not differ significantly between blacks and Caucasians. Ethnic effects ofR,R(-) reboxetine were similar to those observed for S,S(+) reboxetine. Conclusions: The AUCu difference between Asian and black and Caucasian subjects was modest. Tolerability differences among groups were not observed. No dosage adjustment is necessary for Asians or blacks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 13:28:01