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Titolo:
Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule
Autore:
Cilia, J; Piper, DC; Upton, N; Hagan, JJ;
Indirizzi:
GlaxoSmithKline, Neurosci Res, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 155, anno: 2001,
pagine: 135 - 143
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHESUS-MONKEY PERFORMANCE; OPERANT TEST BATTERY; BEHAVIORAL-TEST BATTERY; FOOD-INTAKE; SCHIZOPHRENIA; PHENCYCLIDINE; POLYDIPSIA; FLUOXETINE; DRINKING; DIAZEPAM;
Keywords:
common marmoset; motivation; antipsychotic activity; amphetamine; fluoxetine; diazepam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Cilia, J GlaxoSmithKline, Neurosci Res, New Frontiers Sci Pk,3rd Ave, Harlow CM19 5AW, Essex, England GlaxoSmithKline New Frontiers Sci Pk,3rd Ave Harlow Essex England CM19 5AW
Citazione:
J. Cilia et al., "Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule", PSYCHOPHAR, 155(2), 2001, pp. 135-143

Abstract

Rationale: Motivational effects of psychotropic drugs may contribute to their therapeutic profile and progressive ratio (PR) schedules provide a method of measuring these effects in animals. Objective: Determine effects of selected antipsychotic, psychotomimetic, anxiolytic and antidepressant drugson PR performance in common marmosets. Method: Marmosets were trained to lever press for banana milkshake reinforcement using a PR schedule, in whichthe number of lever presses to achieve successive reinforcements increasedby one until responding ceased (breakpoint). Results: Clozapine administered intramuscularly (0.01-2 mg/kg IM; 30 min pretreatment time (ptt) or by oral gavage (0.1-4 mg/kg PO; 60 min ptt) significantly increased the breakpoint. Independent tests of fluid consumption failed to show enhanced fluid intake after clozapine pretreatment, suggesting this effect was not due to drug induced polydipsia. Neither haloperidol (0.005-0.1 mg/kg PO; 60 min ptt) nor risperidone (0.0025-0.05 mg/kg PO; 60 min ptt) altered breakpoint. Olanzapine (0.01-1 mg/kg PO; 60 min ptt) significantly enhanced the breakpoint at 0.05 mg/kg PO, but the effect was not robust. Amphetamine (0.2-2 mg/kgSC; 30 min ptt) significantly reduced the breakpoint at 2 mg/kg and fluoxetine (0.1-1 mg/kg PO; 60 min ptt) was without effect. Diazepam significantly increased the breakpoint at 0.5 mg/kg PO. Drug-induced polydipsia might play a role in this response as independent tests showed increased fluid consumption following diazepam. Conclusions: These results demonstrate that, unlike other antipsychotics, clozapine over a wide dose range increased the motivational state of marmosets to respond for banana milkshake. This motivational aspect of clozapine's actions may contribute to its unique clinicalprofile and the PR procedure may provide a method for detecting novel antipsychotics with a clozapine-like profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:15:02