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Titolo:
Tryptophan depletion in SSRi-recovered depressed outpatients
Autore:
Spillmann, MK; Van der Does, AJW; Rankin, MA; Vuolo, RD; Alpert, JE; Nierenberg, AA; Rosenbaum, JF; Hayden, D; Schoenfeld, D; Fava, M;
Indirizzi:
Massachusetts Gen Hosp, Depress Clin & Res Program, WAC 812, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 WAC 812, Boston, MA 02114 USA Leiden Univ, Dept Psychol, Leiden, Netherlands Leiden Univ Leiden Netherlands Univ, Dept Psychol, Leiden, Netherlands Leiden Univ, Dept Psychiat, Leiden, Netherlands Leiden Univ Leiden Netherlands Univ, Dept Psychiat, Leiden, Netherlands
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 155, anno: 2001,
pagine: 123 - 127
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID DEPLETION; ANTIDEPRESSANT ACTION; SEROTONIN FUNCTION; RELAPSE; FLUOXETINE; MECHANISM; CHALLENGE; SCALE;
Keywords:
tryptophan depletion; depression; antidepressant; remission; mood effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Fava, M Massachusetts Gen Hosp, Depress Clin & Res Program, WAC 812, 15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St Boston MA USA 02114 02114 USA
Citazione:
M.K. Spillmann et al., "Tryptophan depletion in SSRi-recovered depressed outpatients", PSYCHOPHAR, 155(2), 2001, pp. 123-127

Abstract

Rationale: Recently, a number of studies have challenged the finding that acute tryptophan depletion (TD) increases depressive symptoms in medicated,formerly depressed patients. The present study examined the effects of acute nutritional TD on remitted depressed patients currently treated with selective serotonin reuptake inhibitors. In an attempt to clarify conflicting earlier findings, the effects of a number of clinical variables on outcome were also investigated. Methods: Ten patients underwent TD in a double-blind, controlled, balanced crossover fashion. The control session followed theprocedure of Krahn et al. (1996 Neuropsychopharmacology 15:325-328). Sessions were 5-8 days apart. Results: TD was significantly related to increasedscores on clinician-rated depression and anxiety scales, and on self-rateddepression, anxiety, and somatic symptoms. The control challenge had no effect, despite the fact that the reductions in plasma tryptophan during the central session were unexpectedly high. Some evidence was found for a threshold in the relationship between reduction of plasma tryptophan and mood response. Conclusions: The mood effect of TD in medicated, formerly depressedpatients was confirmed. A threshold may exist for mood effects following TD, implying that recent negative findings may have been caused by insufficient depletion. No other predicting or mediating factors were identified, although the variable "history of response pattern, to medication" deserves further study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:27:58