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Titolo:
Verbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives
Autore:
Gilvarry, CM; Russell, A; Jones, P; Sham, P; Hemsley, D; Murray, RM;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 4, volume: 31, anno: 2001,
pagine: 695 - 704
SICI:
0033-2917(200105)31:4<695:VFIPWS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMBERWELL COLLABORATIVE PSYCHOSIS; NEUROPSYCHOLOGICAL RISK INDICATORS; FIRST-EPISODE SCHIZOPHRENIA; NONPSYCHOTIC RELATIVES; FOLLOW-UP; OBSTETRIC COMPLICATIONS; AUTOIMMUNE-DISEASES; COGNITIVE FUNCTION; EXECUTIVE FUNCTION; NEGATIVE SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Gilvarry, CM Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF England
Citazione:
C.M. Gilvarry et al., "Verbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives", PSYCHOL MED, 31(4), 2001, pp. 695-704

Abstract

Background. Schizophrenic patients are known to have neuropsychological deficits including impaired verbal fluency, but it is not clear whether this latter deficit is: (a) a consequence of overall intellectual deficit; (b) shared with affective psychotic patients; or (c) shared by the relatives of schizophrenic patients; and (d) shared by the relatives of affective psychotic patients. Methods. We administered Thurstone's Verbal Fluency Test to 45 schizophrenic patients and 72 of their relatives, and 30 affective psychotic patients and 53 of their relatives. Subjects were asked to generate as many words aspossible beginning with the letters 'C' and 'S' and the total was taken asthe dependent variable. Subjects also completed the National Adult ReadingTest (NART) to provide a measure of (pre-morbid) IQ. Results. Schizophrenic patients generated significantly fewer words than affective psychotic patients, however adjusting for NART this became non-significant. Schizophrenic (but not affective psychotic) patients generated significantly fewer words than their relatives; again adjusting for NART thisbecame non-significant. Patients who had been exposed to obstetric complications (OC +) and those who had not (OC -) had similarly poor verbal fluency scores. Relatives of OC + schizophrenic patients had superior verbal fluency than relatives of OC - schizophrenic patients and this remained significant after adjustment for NART. Conclusions. The results suggest that some families transmit impairment inverbal fluency as part of a pattern of lower overall IQ. However, in otherfamilies, relatives show largely normal neuropsychological function, and the poorer verbal performance of the schizophrenic member appears to have arisen secondary to his/her exposure to OCs.

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Documento generato il 22/01/20 alle ore 18:52:21