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Titolo:
Decreased tryptophan availability but normal post-synaptic 5-HT2c receptorsensitivity in chronic fatigue syndrome
Autore:
Vassallo, CM; Feldman, E; Peto, T; Castell, L; Sharpley, AL; Cowen, PJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX ept Psychiat, Oxford OX3 7JX, England Univ Oxford, Dept Psychol Med, Dept Biochem, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX Dept Biochem, Oxford OX3 7JX, England John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 4, volume: 31, anno: 2001,
pagine: 585 - 591
SICI:
0033-2917(200105)31:4<585:DTABNP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; SLOW-WAVE SLEEP; META-CHLOROPHENYLPIPERAZINE; SEROTONIN FUNCTION; ACTIVATION; VOLUNTEERS; RITANSERIN; RESPONSES; PLASMA; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Cowen, PJ Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX at, Oxford OX3 7JX, England
Citazione:
C.M. Vassallo et al., "Decreased tryptophan availability but normal post-synaptic 5-HT2c receptorsensitivity in chronic fatigue syndrome", PSYCHOL MED, 31(4), 2001, pp. 585-591

Abstract

Background. Chronic fatigue syndrome (CFS) has been associated with increased prolactin (PRL) responses to the serotonin (5-HT) releasing agent fenfluramine. It is not known whether this abnormality is due to increased 5-HT release or heightened sensitivity of post-synaptic 5-HT receptors. Methods. We measured the increase in plasma PRL produced by the directly acting 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP), in patients with CFS and healthy controls. We also compared the ability of mCPP to lowerslow wave sleep (SWS) in the sleep polysomnogram of both subject groups. Finally, we measured plasma amino-acid levels to determine whether tryptophan availability differed between CFS subjects and controls. Results. mCPP elevated plasma PRL equivalently in patients with CFS and controls. Similarly, the decrease in SWS produced by mCPP did not differ between the two subject groups. Plasma-free tryptophan was significantly decreased in CFS. Conclusions. The sensitivity of post-synaptic 5-HT20 receptors is not increased in patients with CFS. This suggests that the increased PRL response to fenfluramine in CFS is due to elevated activity of pre-synaptic 5-HT neurones. This change is unlikely to be due to increased peripheral availability of tryptophan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:03:41