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Titolo:
First-episode psychosis: lessons from 15 years of research
Autore:
Oosthuizen, P; Emsley, RA;
Indirizzi:
Univ Stellenbosch, Dept Psychiat, ZA-7505 Tygerberg, Cape Town, South Africa Univ Stellenbosch Tygerberg Cape Town South Africa ZA-7505 , South Africa
Titolo Testata:
PRIMARY CARE PSYCHIATRY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 19 - 24
SICI:
1355-2570(200103)7:1<19:FPLF1Y>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; 1ST-EPISODE SCHIZOPHRENIA; DOUBLE-BLIND; TREATMENT RESPONSE; SCHIZOAFFECTIVE DISORDER; TARDIVE-DYSKINESIA; RECEPTOR OCCUPANCY; EARLY INTERVENTION; CLINICAL-RESPONSE; NEGATIVE SYMPTOMS;
Keywords:
first-episode psychosis; negative symptoms; positive symptoms; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Oosthuizen, P Univ Stellenbosch, Dept Psychiat, POB 19063, ZA-7505 Tygerberg, Cape Town,South Africa Univ Stellenbosch POB 19063 Tygerberg Cape Town South Africa ZA-7505
Citazione:
P. Oosthuizen e R.A. Emsley, "First-episode psychosis: lessons from 15 years of research", PRIM CARE P, 7(1), 2001, pp. 19-24

Abstract

Dedicated research efforts over the last 15 years have produced significant findings on the early course of psychotic illness. We now know that patients may experience prodromal symptoms for many years before the onset of illness and may, even after the onset of frank psychosis, remain untreated for many months. Negative and cognitive symptoms are often less severe in thefirst episode. Mood symptoms are more prevalent in this population, whereas brain imaging shows similar, but less severe changes when compared to those in chronic schizophrenia. All symptoms respond better to and at lower doses of medication, with increased sensitivity to side-effects. Second generation antipsychotics or low doses of typical antipsychotics, combined with tailored psychotherapy, are emerging as the treatments of choice. High levels of remission are the role in first-episode psychosis, hut patients oftenbecome noncompliant with pharmacotherapy, leading to high levels of relapse in the first five years after diagnosis and initial treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:52:22