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Titolo:
The analgesic effect of codeine as compared to imipramine in different human experimental pain models
Autore:
Enggaard, TP; Poulsen, L; Arendt-Nielsen, L; Hansen, SH; Bjornsdottir, I; Gram, LF; Sindrup, SH;
Indirizzi:
Odense Univ, Univ So Denmark, Inst Publ Hlth, Odense, Denmark Odense UnivOdense Denmark So Denmark, Inst Publ Hlth, Odense, Denmark Univ Aalborg, Ctr Sensory Motor Interact, Aalborg, Denmark Univ Aalborg Aalborg Denmark r Sensory Motor Interact, Aalborg, Denmark Royal Sch Pharm, Dept Analyt & Pharmaceut Chem, Copenhagen, Denmark Royal Sch Pharm Copenhagen Denmark Pharmaceut Chem, Copenhagen, Denmark
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 92, anno: 2001,
pagine: 277 - 282
SICI:
0304-3959(200105)92:1-2<277:TAEOCA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE ANTAGONIST; POSTHERPETIC NEURALGIA; HEALTHY-VOLUNTEERS; NEUROPATHIC PAIN; POOR METABOLIZERS; MORPHINE; PLACEBO; SPARTEINE; SINGLE; PHARMACOKINETICS;
Keywords:
codeine; imipramine; experimental pain; temporal pain summation; healthy volunteers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Enggaard, TP Odense Univ, Univ So Denmark, Inst Publ Hlth, Odense, DenmarkOdense Univ Odense Denmark Inst Publ Hlth, Odense, Denmark
Citazione:
T.P. Enggaard et al., "The analgesic effect of codeine as compared to imipramine in different human experimental pain models", PAIN, 92(1-2), 2001, pp. 277-282

Abstract

The hypoalgesic effect of single oral doses of 100 mg imipramine and 125 mg codeine was evaluated in a randomised, placebo-controlled. double-blind, 3-way cross-over experiment including 18 healthy volunteers. Pain tests were performed before and 90, 180, 270, 360 and 450 min after medication. The tests included determination of pain tolerance thresholds to pressure. paindetection/tolerance thresholds to single electrical sural nerve stimulation and pain summation at tolerance threshold to repetitive electrical sural nerve stimulation (temporal summation) and pain experienced during the coldpresser test, rated as peak pain intensity, pain average intensity and discomfort. Compared to placebo, imipramine significantly increased pressure pain tolerance threshold (P = 0.03) and increased pain tolerance threshold (P = 0.05) and pain summation threshold (P = 0.03), but not pain detection threshold to electrical stimulation, Imipramine did not cause significant changes in pain perception during the cold presser test. Codeine significantly increased pressure pain tolerance threshold (P = 0.02), pain detection (P= 0.04) and pain tolerance threshold (P = 0.01) and pain summation threshold (P = 0.02) to electrical stimulation. In addition. codeine reduced the pain experienced during the cold presser test (P = 0.04-0.003). It is concluded that both imipramine and codeine inhibit temporal pain summation, whereas only codeine reduces cold presser pain. Pain summation may be a key mechanism in neuropathic pain. Imipramine has a documented effect on such pain conditions on temporal summation. The present study showed that codeine also inhibits temporal summation, which is in line with the clinical observations indicating that opioids relieve neuropathic pain. Copyright (C) 2001 Elsevier Science B.V.. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:03:24