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Titolo:
Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats
Autore:
Rahman, SM; Wang, YM; Yotsumoto, H; Cha, JY; Han, SY; Inoue, S; Yanagita, T;
Indirizzi:
Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan Saga Univ Saga Japan 8408502 iv, Dept Appl Biol Sci, Saga 8408502, Japan Natl Inst Hlth & Nutr, Div Geriatr Hlth & Nutr, Tokyo 162, Japan Natl InstHlth & Nutr Tokyo Japan 162 iatr Hlth & Nutr, Tokyo 162, Japan
Titolo Testata:
NUTRITION
fascicolo: 5, volume: 17, anno: 2001,
pagine: 385 - 390
SICI:
0899-9007(200105)17:5<385:EOCLAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE; ADIPOSE-TISSUE; DOCOSAHEXAENOIC ACIDS; GLUCOSE; WEIGHT; HUMANS; MICE; EXPRESSION; SECRETION; TRANSPORT;
Keywords:
conjugated linoleic acid; leptin; perirenal adipose tissue; brown adipose tissue; gastrocnemius muscle; carnitine-palmitoyltransferase activity; serum lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Yanagita, T Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan Saga Univ Saga Japan 8408502 l Biol Sci, Saga 8408502, Japan
Citazione:
S.M. Rahman et al., "Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats", NUTRITION, 17(5), 2001, pp. 385-390

Abstract

We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial P-oxidation inOtsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction ofserum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/ visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both formsof CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle,and liver in comparison with the OLETF control group. Serum concentrationsof non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:19:07