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Titolo:
A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.
Autore:
Eichhorn, E; Domanski, M; Krause-Steinrauf, H; Anderson, J; Boardman, K; Bristow, M; Carson, P; Colling, C; Greenberg, B; Lavori, P;
Indirizzi:
Univ Texas, SW Med Ctr, Cardiac Catheterizat Lab IIIA2, Dallas, TX 75216 USA Univ Texas Dallas TX USA 75216 theterizat Lab IIIA2, Dallas, TX 75216 USA Univ Texas, Dallas Vet Affairs Med Ctr, Cardiac Catheterizat Lab IIIA2, Dallas, TX 75216 USA Univ Texas Dallas TX USA 75216 theterizat Lab IIIA2, Dallas, TX 75216 USA Albany Med Ctr, Albany, NY 12208 USA Albany Med Ctr Albany NY USA 12208Albany Med Ctr, Albany, NY 12208 USA Albert Einstein Coll Med, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Coll Med, Bronx, NY 10461 USA Baptist Mem Hosp, Memphis, TN 38146 USA Baptist Mem Hosp Memphis TN USA 38146 ist Mem Hosp, Memphis, TN 38146 USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, 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Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA Med Univ S Carolina, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ina, Charleston, SC 29425 USA Minneapolis Heart Inst, Minneapolis, MN USA Minneapolis Heart Inst Minneapolis MN USA eart Inst, Minneapolis, MN USA Montreal Heart Inst, Montreal, PQ, Canada Montreal Heart Inst Montreal PQCanada Heart Inst, Montreal, PQ, Canada Morristown Mem Hosp, Morristown, NJ 07962 USA Morristown Mem Hosp Morristown NJ USA 07962 osp, Morristown, NJ 07962 USA Natl Naval Med Ctr, Bethesda, MD 20889 USA Natl Naval Med Ctr Bethesda MDUSA 20889 Med Ctr, Bethesda, MD 20889 USA Nebraska Heart Inst, Lincoln, NE USA Nebraska Heart Inst Lincoln NE USANebraska Heart Inst, Lincoln, NE USA New England Med Ctr, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 and Med Ctr, Boston, MA 02111 USA Oklahoma Fdn Cardiol Res, Oklahoma City, OK USA Oklahoma Fdn Cardiol Res Oklahoma City OK USA Res, Oklahoma City, OK USA Oregon Hlth Sci Univ, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 i Univ, Portland, OR 97201 USA Penn State Univ Hosp, Hershey, PA 17033 USA Penn State Univ Hosp Hershey PA USA 17033 niv Hosp, Hershey, PA 17033 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA Univ Florida, Shands Hosp, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 nds Hosp, Gainesville, FL 32611 USA St Johns Mercy Med Ctr, St Louis, MO 63141 USA St Johns Mercy Med Ctr St Louis MO USA 63141 Ctr, St Louis, MO 63141 USA Univ Texas SW, Dallas, TX USA Univ Texas SW Dallas TX USAUniv Texas SW, Dallas, TX USA Washington Univ, Sch Med, St Louis, MO 63130 USA Washington Univ St LouisMO USA 63130 iv, Sch Med, St Louis, MO 63130 USA Univ Alabama, Med Ctr, Tuscaloosa, AL 35487 USA Univ Alabama Tuscaloosa AL USA 35487 a, Med Ctr, Tuscaloosa, AL 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55455 USA Univ Minnesota Hosp Minneapolis MN USA 55455 p, Minneapolis, MN 55455 USA Univ Mississippi, Med Ctr, University, MS 38677 USA Univ Mississippi University MS USA 38677 ed Ctr, University, MS 38677 USA Univ Montreal, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 al, Montreal, PQ H3C 3J7, Canada Univ N Carolina, Chapel Hill, NC 27515 USA Univ N Carolina Chapel Hill NCUSA 27515 olina, Chapel Hill, NC 27515 USA Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Med Ctr, Pittsburgh, PA 15260 USA Univ Rochester, Med Ctr, Rochester, NY 14627 USA Univ Rochester RochesterNY USA 14627 r, Med Ctr, Rochester, NY 14627 USA Univ Utah, Hlth Sci Ctr, Salt Lake City, UT 84112 USA Univ Utah Salt LakeCity UT USA 84112 i Ctr, Salt Lake City, UT 84112 USA Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA Univ Wisconsin Hosp & Clin Madison WI USA 53792 in, Madison, WI 53792 USA Watson Clin, Lakeland, FL USA Watson Clin Lakeland FL USAWatson Clin, Lakeland, FL USA Yale New Haven Hosp, New Haven, CT 06504 USA Yale New Haven Hosp New Haven CT USA 06504 Hosp, New Haven, CT 06504 USA Vet Affairs Med Ctr Baltimore, Baltimore, MD 21201 USA Vet Affairs Med CtrBaltimore Baltimore MD USA 21201 timore, MD 21201 USA VAMC Boston, Boston, MA 02130 USA VAMC Boston Boston MA USA 02130VAMC Boston, Boston, MA 02130 USA VAMC Bronx, Bronx, NY 10468 USA VAMC Bronx Bronx NY USA 10468VAMC Bronx, Bronx, NY 10468 USA VAMC Charleston, Charleston, SC 29403 USA VAMC Charleston Charleston SC USA 29403 rleston, Charleston, SC 29403 USA VAMC Dallas, Dallas, TX 75216 USA VAMC Dallas Dallas TX USA 75216VAMC Dallas, Dallas, TX 75216 USA VAMC Denver, Denver, CO 80220 USA VAMC Denver Denver CO USA 80220VAMC Denver, Denver, CO 80220 USA VAMC Durham, Durham, NC 27705 USA VAMC Durham Durham NC USA 27705VAMC Durham, Durham, NC 27705 USA VAMC Fresno, Fresno, CA 93703 USA VAMC Fresno Fresno CA USA 93703VAMC Fresno, Fresno, CA 93703 USA VAMC Hines, 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Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 22, volume: 344, anno: 2001,
pagine: 1659 - 1667
SICI:
0028-4793(20010531)344:22<1659:ATOTBB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; ADRENERGIC-BLOCKADE; RACIAL-DIFFERENCES; CARDIOMYOPATHY; METOPROLOL; CARVEDILOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Eichhorn, E Univ Texas, SW Med Ctr, Cardiac Catheterizat Lab IIIA2, 4500 SLancaster, Dallas, TX 75216 USA Univ Texas 4500 S Lancaster Dallas TX USA 75216 , TX 75216 USA
Citazione:
E. Eichhorn et al., "A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.", N ENG J MED, 344(22), 2001, pp. 1659-1667

Abstract

Background: Although beta-adrenergic-receptor antagonists reduce morbidityand mortality in patients with mild-to-moderate chronic heart failure, their effect on survival in patients with more advanced heart failure is unknown. Methods: A total of 2708 patients with heart failure designated as New York Heart Association (NYHA) functional class III (in 92 percent of the patients) or IV (in 8 percent) and a left ventricular ejection fraction of 35 percent or lower were randomly assigned to double-blind treatment with eitherbucindolol (1354 patients) or placebo (1354 patients) and followed for theprimary end point of death from any cause. Results: The data and safety monitoring board recommended stopping the trial after the seventh interim analysis. At that time, there was no significant difference in mortality between the two groups (unadjusted P=0.16). The results presented here are based on complete follow-up at the time of studytermination (average, 2.0 years). There were a total of 449 deaths in the placebo group (33 percent) and 411 deaths in the bucindolol group (30 percent, adjusted P=0.13). The risk of the secondary end point of death from cardiovascular causes was lower in the bucindolol group (hazard ratio, 0.86; 95 percent confidence interval, 0.74 to 0.99), as was the risk of heart transplantation or death. In a subgroup analysis, there was a survival benefit in nonblack patients. Conclusions: In a demographically diverse group of patients with NYHA class III and IV heart failure, bucindolol resulted in no significant overall survival benefit. (N Engl J Med 2001;344:1659-67. ) Copyright (C) 2001 Massachusetts Medical Society.

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Documento generato il 09/04/20 alle ore 10:51:34