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Titolo:
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders
Autore:
Vivo, M; de Vera, N; Cortes, R; Mengod, G; Camon, L; Martinez, E;
Indirizzi:
CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona 08036, Spain CSIC Barcelona Spain 08036 elona, Dept Neurochem, Barcelona 08036, Spain CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Pharmacol & Toxicol, Barcelona 08036, Spain CSIC Barcelona Spain 08036 t Pharmacol & Toxicol, Barcelona 08036, Spain
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 304, anno: 2001,
pagine: 107 - 111
SICI:
0304-3940(20010518)304:1-2<107:PITBGO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; CHANNELS; DISEASE;
Keywords:
putrescine; spermidine; spermine; Parkinson's disease; Huntington's disease; progressive supranuclear palsy; basal ganglia; high pressure liquid chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, E CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem, CRossello 161,6th Floor, Barcelona 08036, Spain CSIC C Rossello 161,6th Floor Barcelona Spain 08036 36, Spain
Citazione:
M. Vivo et al., "Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders", NEUROSCI L, 304(1-2), 2001, pp. 107-111

Abstract

The distribution of polyamines in the human basal ganglia was examined, using dansyl-derivatives and high pressure liquid chromatography with fluorimetric detection. A heterogeneous distribution of putrescine, spermidine (SD) and spermine (SM) was observed in control brains. A consistent negative correlation between SD and SM content and age was found in different brain areas. These results suggest an involvement of polyamines in age-related changes occurring in white-matter, When the influence of degenerative movementdisorders -Parkinson's disease, Huntington's disease (HD) and progressive supranuclear palsy-was analyzed, significant changes were observed only in HD, where a decrease in the concentration of SM was found in the putamen. These results suggest that in advanced stages of neurodegenerative processes, polyamines maintain their regulation. Only in the presence of severe atrophy, SM concentration is reduced. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:32:55