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Titolo:
Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat
Autore:
Kubo, K; Arai, O; Ogata, R; Omura, M; Hori, T; Aou, S;
Indirizzi:
Kyushu Univ 60, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 8128582, Japan Kyushu Univ 60 Fukuoka Japan 8128582 rat Physiol, Fukuoka 8128582, Japan Dokkyo Univ, Sch Med, Dept Physiol & Biol Informat, Mibu, Tochigi 3210293,Japan Dokkyo Univ Mibu Tochigi Japan 3210293 ormat, Mibu, Tochigi 3210293,Japan Kyushu Univ 60, Grad Sch Med Sci, Dept Hyg, Fukuoka 8128582, Japan Kyushu Univ 60 Fukuoka Japan 8128582 i, Dept Hyg, Fukuoka 8128582, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 304, anno: 2001,
pagine: 73 - 76
SICI:
0304-3940(20010518)304:1-2<73:ETBADT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETHYLSTILBESTROL; GROWTH; GLAND;
Keywords:
environmental endocrine disrupter; bisphenol A; sexual differentiation; open field activity; avoidance behavior; locus coeruleus; no-observed-adverse-effect level; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Aou, S Kyushu Univ 60, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 8128582, Japan Kyushu Univ 60 Fukuoka Japan 8128582 siol, Fukuoka 8128582, Japan
Citazione:
K. Kubo et al., "Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat", NEUROSCI L, 304(1-2), 2001, pp. 73-76

Abstract

This study rested the effect of exposure to bisphenol A (BPA) early in life on the sexual differentiation in the brain and behavior in Wister rats. We administered BPA only to mother rats during pregnancy and lactation at a dosage of approximately 1.5 mg/kg per day far less than the no-observed-adverse-effect level (NOAEL; 50 mg/kg per day). Control female offspring showed a higher activity, a lower avoidance memory, and larger locus coeruleus than the male controls, while the BPA-exposed group did not show any sexual dimorphism. BPA did not affect the reproductive organs or sex hormones. Ourresults suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:35:17