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Titolo:
Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
Autore:
Jung, CW; Rong, YQ; Doctrow, S; Baudry, M; Malfroy, B; Xu, ZS;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 rmacol, Worcester, MA 01655 USA Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Eukarion Inc, Bedford, MA 01730 USA Eukarion Inc Bedford MA USA 01730Eukarion Inc, Bedford, MA 01730 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 304, anno: 2001,
pagine: 157 - 160
SICI:
0304-3940(20010525)304:3<157:SSDMRO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MODEL; ALS; CATALASE; DAMAGE; DEGENERATION; MECHANISM; SCAVENGER; MUTATION; BENEFIT; SOD1;
Keywords:
motor neuron; neurodegenerative disease; neurodegeneration; antioxidant; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, ZS Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, 55 Lake Ave North, Worcester, MA 01655 USA Univ Massachusetts 55 Lake Ave North Worcester MA USA 01655 655 USA
Citazione:
C.W. Jung et al., "Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model", NEUROSCI L, 304(3), 2001, pp. 157-160

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes motoneuron degeneration, paralysis and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause of this disease. It is widely suspected that increased reactive oxidative species (ROS) is involved in motoneuron degeneration but whether such an involvement plays a role in ALS progression in vivo is uncertain. We treated mice expressing human mutant SOD1 G93A with EUK-8 and EUK-134, two synthetic SOD/catalase mimetics that have shown efficacy in several animal models of human diseases. These treatments reduced levels of oxidative stress and prolonged survival. The results suggest that oxidative stress plays an active role in ALS and illustrate the potential for treatment strategies aimed specifically against ROS, (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:27:03