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Titolo:
Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients
Autore:
Surma-aho, O; Niemela, M; Vilkki, J; Kouri, M; Brander, A; Salonen, O; Paetau, A; Kallio, M; Pyykkonen, J; Jaaskelainen, J;
Indirizzi:
Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00100 chol, SF-00100 Helsinki, Finland Haartman Inst, Dept Pathol, Helsinki, Finland Haartman Inst Helsinki Finland man Inst, Dept Pathol, Helsinki, Finland Univ Helsinki Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki Hosp Helsinki Finland osp, Dept Neurol, Helsinki, Finland Univ Helsinki Hosp, Dept Radiol, Helsinki, Finland Univ Helsinki Hosp Helsinki Finland osp, Dept Radiol, Helsinki, Finland Univ Helsinki Hosp, Dept Neurosurg, Helsinki, Finland Univ Helsinki Hosp Helsinki Finland , Dept Neurosurg, Helsinki, Finland
Titolo Testata:
NEUROLOGY
fascicolo: 10, volume: 56, anno: 2001,
pagine: 1285 - 1290
SICI:
0028-3878(20010522)56:10<1285:ALEOBR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE FUNCTIONS; SURVIVORS; TUMORS; DEMENTIA; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Surma-aho, O Helsinki Univ Hosp, Dept Neurosurg, Topeliuksenkatu 5, Helsinki 00260, Finland Helsinki Univ Hosp Topeliuksenkatu 5 Helsinki Finland 00260
Citazione:
O. Surma-aho et al., "Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients", NEUROLOGY, 56(10), 2001, pp. 1285-1290

Abstract

Objective: To study the long-term effects of radiotherapy on cognitive function in adult patients operated on for low-grade glioma. Methods: A cohortof 160 patients who underwent surgery for low-grade gliomas of cerebral hemisphere between 1980 and 1992 in a single institution serving a defined population was studied. At a mean follow-up time of 7 years, 28 of the 101 patients who had postoperative irradiation (and no second surgery or chemotherapy) were still alive and eligible for MRI and neuropsychological study. Twenty-three of 59 patients who did not have radiotherapy, second surgery, or chemotherapy were alive and eligible at a mean of 10 years. Results: The group that had postoperative irradiation performed significantly worse thanthe group that did not in cognitive tests. This difference was not accounted for by histologic diagnosis; location, extent of removal, or progressionof the tumor; or any patient factor. Leukoencephalopathy was more severe in the group that had postoperative irradiation than in the group without radiotherapy, and correlated to poor memory performances only in the postoperative radiotherapy group. Average Karnofsky performance scale score was significantly lower in the group that had postoperative irradiation than in the group that did not. Conclusion: In adults with low-grade glioma, postoperative radiotherapy poses a significant risk of long-term leukoencephalopathy and cognitive impairment.

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Documento generato il 23/01/20 alle ore 03:56:23