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Titolo:
Risk factors for Parkinson's disease: The Leisure World cohort study
Autore:
Paganini-Hill, A;
Indirizzi:
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA Univ SoCalif Los Angeles CA USA , Dept Prevent Med, Los Angeles, CA USA
Titolo Testata:
NEUROEPIDEMIOLOGY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 118 - 124
SICI:
0251-5350(200105)20:2<118:RFFPDT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-FREQUENCY QUESTIONNAIRE; CIGARETTE-SMOKING; DIETARY FACTORS; PAST INTAKE; AGE; EPIDEMIOLOGY; PREVALENCE; DOPAMINE; CAFFEINE; ASSOCIATION;
Keywords:
Parkinson's disease; risk factors; smoking; alcohol; coffee; hypertension; vitamins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Paganini-Hill, A 842 Manzanita Dr, Laguna Beach, CA 92651 USA 842 Manzanita Dr Laguna Beach CA USA 92651 CA 92651 USA
Citazione:
A. Paganini-Hill, "Risk factors for Parkinson's disease: The Leisure World cohort study", NEUROEPIDEM, 20(2), 2001, pp. 118-124

Abstract

We conducted a case-control study nested within a prospective cohort studyof 13,979 residents of Leisure World Laguna Hills, a retirement community in southern California, for etiologic clues for Parkinson's disease (PD). Between 1981 (when first mailed a health survey) and 1998, we identified 395PD cases from death certificates, hospital discharge diagnoses and a 1992 follow-up questionnaire. Six controls were individually matched on sex, birth date (+/-2 years), vital status and, if dead, death date (+/-1 year) to each case. Baseline characteristics of the 395 cases and 2,320 controls were analyzed as potential PD risk factors. The risk of PD was significantly reduced among smokers, hypertensives, coffee drinkers and alcohol consumers,and significantly increased among those with 3 or more children and with ahigh intake of total vitamin A and dietary vitam in C. The multivariate odds ratios (95% confidence intervals) were 0.42 (0.22-0.80) for current cigarette smokers of 1+ pack/day, 0.62 (0.48-0.80) for current users of hypertensive medication, 0.71 (0.52-0.95) for coffee drinkers of 2+ cups/day and 0.77 (0.58-1.03) for drinkers of 2+ alcoholic drinks! day. Risk increased with increasing number of children (1.25 for 1, 1.34 for 2 and 1.90 for 3+ children; p for trend = 0.0003). The increased risks among individuals in thehighest third of total vitamin A intake and of dietary vitamin C intake were no longer statistically significant after adjusting for the other variables. These findings suggest several environmental factors that may be related to the development of PD and support a multifactorial etiology. Copyright (C) 2000 S.Karger AG, Basel.

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Documento generato il 04/12/20 alle ore 12:55:55