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Titolo:
Verb comprehension in frontotemporal degeneration: The role of grammatical, semantic and executive components
Autore:
Rhee, J; Antiquena, P; Grossman, M;
Indirizzi:
Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROCASE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 173 - 184
SICI:
1355-4794(2001)7:2<173:VCIFDT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE NONFLUENT APHASIA; ADULT AGE-DIFFERENCES; WORKING-MEMORY; SENTENCE COMPREHENSION; ALZHEIMERS-DISEASE; LANGUAGE COMPREHENSION; INDIVIDUAL-DIFFERENCES; BRAIN ACTIVATION; PROCESSING-SPEED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Grossman, M Univ Penn, Med Ctr, Dept Neurol, 3 Gates,3400 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3 Gates,3400 Spruce St Philadelphia PA USA 19104 USA
Citazione:
J. Rhee et al., "Verb comprehension in frontotemporal degeneration: The role of grammatical, semantic and executive components", NEUROCASE, 7(2), 2001, pp. 173-184

Abstract

Verb comprehension has been associated with the left frontal cortex, but assessments of verb comprehension in frontotemporal degeneration (FTD) have been rare. This study assessed word-picture matching for verbs and nouns under two conditions: alone (baseline) and during concurrent performance of asecondary task. In addition, we correlated FTD patients' verb comprehension with their performance on measures of executive resources and language. We found that FTD patients were significantly less accurate and required significantly longer to make word-picture matching decisions about verbs compared with nouns at baseline. During concurrent performance of a secondary task, accuracy decreased and response latencies became prolonged for nouns tothe point that these measures equaled the performance with verbs at baseline. Verb comprehension accuracy was significantly correlated with the performance on executive measures such as category naming fluency, the Stroop test, and the Trail Making Test Part B (Trails B test). Assessment of FTD patient subgroups revealed distinct profiles of performance, suggesting that several factors contribute to verb comprehension in FTD, Verb comprehension in FTD patients with a dysexecutive syndrome (EXEC, n = 10) was sensitive to concurrent performance of a secondary task, and their verb comprehension accuracy correlated with the time required to complete executive measures such as the Stroop test and the Trails B test. This suggested a relationshipbetween impaired verb comprehension and limited information-processing speed in EXEC patients. Verb comprehension in patients with a progressive non-fluent aphasia (PNFA, n = 7) was not selectively influenced by executive resources. Instead, verb comprehension accuracy in PNFA was significantly correlated with sentence comprehension accuracy, suggesting that grammatical aspects of verbs play a crucial role in their verb comprehension difficulty. Although we studied only a small number of patients with semantic dementia(SD, n = 4), we observed significant verb comprehension difficulty that was minimally influenced by executive resources and was unrelated to sentencecomprehension. It is possible that impaired verb comprehension in SD is related in part to the degradation of semantic feature knowledge.

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Documento generato il 26/01/20 alle ore 16:50:54