Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Structural brain changes of schizophrenic patients. From focal pathology to network disturbances
Autore:
Falkai, P; Vogeley, K; Maier, W;
Indirizzi:
Univ Bonn, Klin Psychiat & Psychotherapie, Bonn, Germany Univ Bonn Bonn Germany n, Klin Psychiat & Psychotherapie, Bonn, Germany
Titolo Testata:
NERVENARZT
fascicolo: 5, volume: 72, anno: 2001,
pagine: 331 - 341
SICI:
0028-2804(200105)72:5<331:SBCOSP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Soggetto:
PLANUM TEMPORALE ASYMMETRY; CEREBRAL BLOOD-FLOW; GRAY-MATTER VOLUME; MAGNETIC-RESONANCE; PREFRONTAL CORTEX; AUDITORY HALLUCINATIONS; CEREBELLAR CIRCUITRY; COGNITIVE DYSMETRIA; CINGULATE CORTEX; LIMBIC SYSTEM;
Keywords:
schizophrenia; brain structure; heteromodal association cortex; dysconnectivity syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Falkai, P Univ Bonn, Klin Psychiat & Psychotherapie, Sigmund Freud Str 25,Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany 25, Bonn, Germany
Citazione:
P. Falkai et al., "Structural brain changes of schizophrenic patients. From focal pathology to network disturbances", NERVENARZT, 72(5), 2001, pp. 331-341

Abstract

Schizophrenia is a brain disorder characterized by a heterogeneous clinical symptomatology. Accordingly, many structural brain changes are not associated directly with clinical symptoms. These structural changes can be detected in the frontotemporal cortex and may correlate with the course of the disease. The most important etiological concept is the neurodevelopmental hypothesis according to which developmental, morphologically detectable changes predispose for the acquisition of schizophrenia. The relevance of neurodegenerative components also remains to be determined. However, it is becoming increasingly clear that schizophrenia is not associated with pathological changes in a circumscribed brain region but with widely distributed morphological changes. Presently, the leading hypothesis for explaining these changes is a frontotemporolimbic network disturbance with cytoarchitectural changes in the heteromodal association cortex. Present research therefore focuses on testing this theory using functional imaging on a macroscopic level and examination of the neuronal cytoarchitecture on a microscopic level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:25:48