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Titolo:
Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formation
Autore:
Small, SA; Nava, AS; Perera, GM; DeLaPaz, R; Mayeux, R; Stern, Y;
Indirizzi:
Columbia Univ Coll Phys & Surg, Taub Inst Alzheimers Dis & Aging Brain, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 4, anno: 2001,
pagine: 442 - 449
SICI:
1097-6256(200104)4:4<442:CMUMEA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL TEMPORAL-LOBE; FUNCTIONAL-DIFFERENTIATION; CORTICAL AFFERENTS; TERM POTENTIATION; ENTORHINAL CORTEX; ORGANIZATION; MONKEY; REPRESENTATION; ACTIVATIONS; FMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Small, SA Columbia Univ Coll Phys & Surg, Taub Inst Alzheimers Dis & AgingBrain, 630 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St New York NY USA 10032
Citazione:
S.A. Small et al., "Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formation", NAT NEUROSC, 4(4), 2001, pp. 442-449

Abstract

Circuits within the hippocampal formation are active during memory processing. Here we used functional magnetic resonance imaging (fMRI) to examine multiple sites across the long axis of the hippocampal formation while subjects performed different phases of an associative memory task, learning to associate faces with names. Viewing faces and hearing names in isolation resulted in separate hippocampal activation patterns. Pairing faces with namesresulted a spatially redistributed activation pattern, rather than a simple summation of the activation patterns resulting from viewing faces and hearing names in isolation. Recalling names when cued with faces reactivated apattern similar to that found during paired training. Finally, the activation patterns representing faces and names were found to be experience dependent, emerging with repeated exposure. Interpreted in the context of hippocampal anatomy and physiology, these findings reveal hippocampal circuit mechanisms that underlie memory encoding and retrieval.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:30:43