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Titolo:
Activation of the left amygdala to a cognitive representation of fear
Autore:
Phelps, EA; OConnor, KJ; Gatenby, JC; Gore, JC; Grillon, C; Davis, M;
Indirizzi:
NYU, Dept Psychol, New York, NY 10003 USA NYU New York NY USA 10003NYU, Dept Psychol, New York, NY 10003 USA MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA Yale Univ, Sch Med, Dept Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ed, Dept Radiol, New Haven, CT 06520 USA NIMH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Bethesda, MD 20892 USA Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 4, anno: 2001,
pagine: 437 - 441
SICI:
1097-6256(200104)4:4<437:AOTLAT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATED STARTLE; NEURONS; HUMANS; BRAIN; ANTICIPATION; RESPONSES; REFLEX; STRESS; CORTEX; FMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Phelps, EA NYU, Dept Psychol, 6 Washington Pl,8th Floor, New York, NY 10003 USA NYU 6 Washington Pl,8th Floor New York NY USA 10003 Y 10003 USA
Citazione:
E.A. Phelps et al., "Activation of the left amygdala to a cognitive representation of fear", NAT NEUROSC, 4(4), 2001, pp. 437-441

Abstract

We examined the neural substrates involved when subjects encountered an event linked verbally, but not experientially, to an aversive outcome. This instructed fear task models a primary way humans learn about the emotional nature of events. Subjects were told that one stimulus (threat) represents an aversive event (a shock may be given), whereas another (safe) represents safety (no shock will be given). Using functional magnetic resonance imaging (fMRI), activation of the left amygdala was observed in response to threat versus safe conditions, which correlated with the expression of the fear response as measured by skin conductance. Additional activation observed inthe insular cortex is proposed to be involved in conveying a cortical representation of fear to the amygdala. These results suggest that the neural substrates that support conditioned fear across species have a similar but somewhat different role in more abstract representations of fear in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:20:33