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Titolo:
Thalamocortical NMDA conductances and intracortical inhibition can explaincortical temporal tuning
Autore:
Krukowski, AE; Miller, KD;
Indirizzi:
Univ Calif San Francisco, WM Keck Ctr Integrat Neurosci, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Biophys Grad Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Otolaryngol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sloan Swartz Ctr Theoret Neurobiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 4, anno: 2001,
pagine: 424 - 430
SICI:
1097-6256(200104)4:4<424:TNCAII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT VISUAL-CORTEX; LATERAL GENICULATE-NUCLEUS; CELL RECEPTIVE-FIELDS; D-ASPARTATE RECEPTORS; SUSPECTED INTERNEURONS; AXONAL PROPERTIES; EFFERENT NEURONS; AWAKE RABBIT; POSTSYNAPTIC POTENTIALS; DIRECTION SELECTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Krukowski, AE Univ Calif San Francisco, WM Keck Ctr Integrat Neurosci, SanFrancisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 143 USA
Citazione:
A.E. Krukowski e K.D. Miller, "Thalamocortical NMDA conductances and intracortical inhibition can explaincortical temporal tuning", NAT NEUROSC, 4(4), 2001, pp. 424-430

Abstract

Cells in cerebral cortex fail to respond to fast-moving stimuli that evokestrong responses in the thalamic nuclei innervating the cortex. The reasonfor this behavior has remained a mystery. We study an experimentally motivated model of the thalamic input-recipient layer of cat primary visual cortex that accounts for many aspects of cortical orientation tuning. In this circuit, inhibition dominates over excitation, but temporal modulations of excitation and inhibition occur out of phase with one another, allowing excitation to transiently drive cells. We show that this circuit provides a natural explanation of cortical low-pass temporal frequency tuning, provided N-methyl-D-aspartate (NMDA) receptors are present in thalamocortical synapses in proportions measured experimentally. This suggests a new and unanticipated role for NMDA conductances in shaping the temporal response propertiesof cortical cells, and suggests that common cortical circuit mechanisms underlie both spatial and temporal response tuning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 08:11:40