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Titolo:
The impact of 'bursting' thalamic impulses at a neocortical synapse
Autore:
Swadlow, HA; Gusev, AG;
Indirizzi:
Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 , Dept Psychol, Storrs, CT 06269 USA Russian Acad Med Sci, Moscow Brain Res Inst, Moscow 103064, Russia RussianAcad Med Sci Moscow Russia 103064 es Inst, Moscow 103064, Russia
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 4, anno: 2001,
pagine: 402 - 408
SICI:
1097-6256(200104)4:4<402:TIO'TI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; CAT VISUAL-CORTEX; FUNCTIONAL-ORGANIZATION; INHIBITORY INTERNEURONS; NEURONS; CELLS; RABBIT; RAT; ELECTROPHYSIOLOGY; TRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Swadlow, HA Univ Connecticut, Dept Psychol, 406 Babbidge Rd, Storrs, CT 06269 USA Univ Connecticut 406 Babbidge Rd Storrs CT USA 06269 06269 USA
Citazione:
H.A. Swadlow e A.G. Gusev, "The impact of 'bursting' thalamic impulses at a neocortical synapse", NAT NEUROSC, 4(4), 2001, pp. 402-408

Abstract

Considerable effort has gone into understanding the mechanisms underlying high-frequency 'bursting' of thalamocortical impulses, their sensory information content and their involvement in perception. However, little is knownabout the influence of such impulses on their cortical targets. Here we follow bursting thalamic impulses to their terminus at the thalamocortical synapse of the awake rabbit, and examine their influence on a class of somatosensory cortical neurons. We show that thalamic bursts potently activate cortical circuits. Initial impulses of each burst have a greatly enhanced ability to elicit cortical action potentials, and later impulses in the burst further raise the probability of eliciting spikes. In some cases, multiple cortical spikes result from a single burst. Moreover, we show that the interval preceding each burst is crucial for generating the enhanced cortical response. The powerful activation of neocortex by thalamocortical bursts is fully consistent with an involvement of these impulses in perceptual/attentional processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:43:09