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Titolo:
Pathologic classification of rhabdomyosarcomas and correlations with molecular studies
Autore:
Parham, DM;
Indirizzi:
Arkansas Childrens Hosp, Dept Pathol, Little Rock, AR 72202 USA Arkansas Childrens Hosp Little Rock AR USA 72202 ittle Rock, AR 72202 USA Univ Arkansas Med Sci, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 5, volume: 14, anno: 2001,
pagine: 506 - 514
SICI:
0893-3952(200105)14:5<506:PCORAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; SOFT-TISSUE SARCOMAS; INTERGROUP RHABDOMYOSARCOMA; CHILDHOOD RHABDOMYOSARCOMA; EMBRYONAL RHABDOMYOSARCOMA; HISTOPATHOLOGICAL CLASSIFICATION; ALVEOLAR RHABDOMYOSARCOMA; CHROMOSOME INSTABILITY; DNA METHYLTRANSFERASE; WILMS-TUMOR;
Keywords:
classification; cytogenetics; molecular biology; pathology; review; rhabdomyosarcoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Parham, DM Arkansas Childrens Hosp, Dept Pathol, Slot 820,800 Marshall St,Little Rock, AR 72202 USA Arkansas Childrens Hosp Slot 820,800 Marshall StLittle Rock AR USA 72202
Citazione:
D.M. Parham, "Pathologic classification of rhabdomyosarcomas and correlations with molecular studies", MOD PATHOL, 14(5), 2001, pp. 506-514

Abstract

Rhabdomyosarcoma, the most common soft-tissue malignancy of childhood and adolescence, comprises a group of differing pathobiologic entities linked by their common propensity for formation of neoplastic skeletal muscle, a feature that results from biological forces related to aberrant transcriptionsignals and the resultant production of myo-genic proteins. At a molecularlevel, however, rhabdomyosarcomas form a heterogeneous group that can be subdivided into distinct clinicopathologic entities based on morphologic appearance and genetic makeup. These differing morphologic features were recognized in the mid-1900s by Horn and Enterline T Vith their division of rhabdomyosarcomas into embryonal, alveolar, botryoid, and pleomorphic subtypes, More recent histologic and biologic studies have resulted in description ofadditional entities, such as spindle cell and anaplastic rhabdomyosarcoma,and refinements in recognition of the original entities, such as solid-alveolar rhabdomyosarcoma Familiarity with newer classifications and their relationship to molecular aberrations is key to stratifying patients on current therapeutic protocols and proposed innovative genetic therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:03:38