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Titolo:
The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin
Autore:
Olas, B; Wachowicz, B; Szewczuk, J; Saluk-Juszczak, J; Kaca, W;
Indirizzi:
Univ Lodz, Inst Biochem, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz Poland PL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Polish Acad Sci, Ctr Microbiol & Virol, Lodz, Poland Polish Acad Sci Lodz Poland ad Sci, Ctr Microbiol & Virol, Lodz, Poland
Titolo Testata:
MICROBIOS
fascicolo: 410, volume: 105, anno: 2001,
pagine: 7 - 13
SICI:
0026-2633(2001)105:410<7:TEOROT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPLATELET ACTIVITY; BLOOD-PLATELETS; RED WINE; ACTIVATION;
Keywords:
blood platelet secretion; resveratrol; lipopolysaccharide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Olas, B Univ Lodz, Inst Biochem, Dept Gen Biochem, Banacha 12-16, PL-90237Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 L-90237 Lodz, Poland
Citazione:
B. Olas et al., "The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin", MICROBIOS, 105(410), 2001, pp. 7-13

Abstract

The effect of resveratrol (trans-3,4',5-trihydroxystilbene) on the releaseof adenine nucleotides and proteins from blood platelets activated by lipopolysaccharide (FPS), from Proteus mirabilis and by thrombin, were studied. Thrombin stimulated the release of adenine nucleotides from dense granulesand proteins from or-granules. The LPS (0.3 mug/10(8) platelets, 5 min, 37degreesC), like thrombin (2.5 U/10(8) platelets. 5 min, 37 degreesC) was found to cause a release of adenine nucleotides and proteins (p <0.05). Resveratrol (6.25-100 mug/ml, 30 min. 37 degreesC) had a different effect on the platelet release reaction caused by either LPS or thrombin. The results indicated that resveratrol inhibited, in dose-dependent manner, the secretory process (release of adenine nucleotides and proteins) induced by thrombin(p <0.05), but it significantly stimulated the liberation of proteins fromblood platelets activated by LPS (p <less than>0.05).

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Documento generato il 28/01/20 alle ore 20:53:27