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Titolo:
POTENTIAL EFFICACY OF A DELTA-5-AMINOLEVULINIC ACID BIOADHESIVE GEL FORMULATION FOR THE PHOTODYNAMIC TREATMENT OF LESIONS OF THE GASTROINTESTINAL-TRACT IN MICE
Autore:
VONARX V; ELEOUET S; CARRE J; IOSS P; GOUYETTE A; LERAY AM; MERLE C; LAJAT Y; PATRICE T;
Indirizzi:
HOP NORD LAENNEC,DEPT LASER F-44035 NANTES FRANCE HOP NORD LAENNEC,DEPT LASER F-44035 NANTES FRANCE FAC PHARM,PHARM GALEN LAB F-44035 NANTES FRANCE
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 7, volume: 49, anno: 1997,
pagine: 652 - 656
SICI:
0022-3573(1997)49:7<652:PEOADA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARRETTS-ESOPHAGUS; PROTOPORPHYRIN-IX; THERAPY; ADENOCARCINOMA; DELIVERY; ABLATION; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
V. Vonarx et al., "POTENTIAL EFFICACY OF A DELTA-5-AMINOLEVULINIC ACID BIOADHESIVE GEL FORMULATION FOR THE PHOTODYNAMIC TREATMENT OF LESIONS OF THE GASTROINTESTINAL-TRACT IN MICE", Journal of Pharmacy and Pharmacology, 49(7), 1997, pp. 652-656

Abstract

delta fi-aminolevulinic acid (ALA) bioadhesive gel has been developedand evaluated in an in-vivo mouse model for photodynamic treatment ofgastric cancer or Barrett's oesophagus. Four gels were tested: noveonAA-1, keltrol T, lutrol and blanose. An initial in-vitro study of geladhesion showed that noveon and keltrol had longer polyethylene transit times than lutrol and blanose. In-vivo assays indicated that protoporphyrin IX was synthesized by gastric mucosa when ALA-noveon and ALA-lutrol were used (preferable results for noveon). Keltrol was eliminated from the study after these investigations. Only ALA-noveon gel was retained for studies of the relationship between ALA dose and fluorescence. Fluorescence measurements in-vivo showed that ALA concentration and application time had an influence on protoporphyrin IX synthesis. Maximum intensity (2091 counts s(-1)) was found with 2 mg mL(-1) ALA, and fluorescence intensities differed with application time, reaching 1805 counts s(-1) after 240 min. ALA-noveon, showing good adhesion andenabling efficient diffusion of ALA at a pH < 6, was considered the best formulation for maintaining ALA stability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:18:02