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Titolo:
MRI studies of the neurotoxic effects of L-2-chloropropionic acid on rat brain
Autore:
Williams, RE; Prior, M; Bachelard, HS; Waterton, JC; Checkley, D; Lock, EA;
Indirizzi:
Univ Nottingham, Sch Phys & Astron, Magnet Resonance Ctr, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England AstraZeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England AstraZeneca Pharmaceut Macclesfield Cheshire England SK10 4TG re, England Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ e, England
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 2, volume: 19, anno: 2001,
pagine: 133 - 142
SICI:
0730-725X(200102)19:2<133:MSOTNE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITOTOXIC LESIONS; TEMPORAL EVOLUTION; INTOXICATION; ISCHEMIA;
Keywords:
L-2-chloropropionic acid; diffusion weighted imaging; T-2 weighted imaging; oedema; cerebellar granule cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, RE Univ Nottingham, Sch Phys & Astron, Magnet Resonance Ctr, Univ Pk, Nottingham NG7 2RD, England Univ Nottingham Univ Pk Nottingham England NG7 2RD , England
Citazione:
R.E. Williams et al., "MRI studies of the neurotoxic effects of L-2-chloropropionic acid on rat brain", MAGN RES IM, 19(2), 2001, pp. 133-142

Abstract

L-2-Chloropropionic acid (L-CPA) is selectively toxic to rat cerebellar granule cells; necrosis is first observed about 36 hours after administrationof L-CPA (750 mg/kg p.o.) becoming more marked by 48 h. Parallel to the onset of cell death an increase in cerebellar water content and sodium concentration has been reported suggesting an oedematous reaction. In this study T-2-weighted (T2WI) and diffusion weighted (DWI) imaging were used to detect the development of neuronal damage in the cerebellum of rats as a result of exposure to L-CPA. T2WI and DWI were not able to detect cerebellar abnormalities at 37 h post-dosing except for a slight swelling of the cerebellumHowever, at 48 h post-dosing when cerebellar swelling and granule cell necrosis were marked, T2WI and DWI hyperintensities were observed in the cerebellum. Therefore, under the conditions of this study, MRI was not able to detect abnormalities in the cerebellum prior to the onset of the clinical signs of neurotoxicity or at the time of early histological changes. T2WI also suggested a marked increase in the amount of fluid in the ventricular system of rats 37 and 48 h after dosing; fluid accumulation was observed in all animals studied whether or not necrosis was detected. The occurrence of T2WI hyperintensity in the forebrain lead us to discover a new lesion in thehabenular nucleus. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:59:33