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Titolo:
A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A(2) signaling pathway
Autore:
Nomura, T; Nishizaki, T; Enomoto, T; Itoh, H;
Indirizzi:
Kobe Univ, Sch Med, Dept Physiol, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Fac Human Sci, Dept Human Environm, Nada Ku, Kobe, Hyogo 6578501, Japan Kobe Univ Kobe Hyogo Japan 6578501 m, Nada Ku, Kobe, Hyogo 6578501, Japan Kobe Univ, Sch Med, Dept Pathol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 25, volume: 68, anno: 2001,
pagine: 2885 - 2891
SICI:
0024-3205(20010511)68:25<2885:ALFOHN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACH RECEPTOR CURRENTS; PROTEIN-KINASE-C; ARACHIDONIC-ACID; TERM POTENTIATION; SYNAPTIC TRANSMISSION; ENHANCEMENT; MODULATION; ACTIVATION; NEURONS; RELEASE;
Keywords:
phospholipase A(2); unsaturated free fatty acids; lysophosphatidylcholine; facilitation; hippocampal neurotransmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Nishizaki, T Hyogo Coll Med, Dept Physiol, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
T. Nomura et al., "A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A(2) signaling pathway", LIFE SCI, 68(25), 2001, pp. 2885-2891

Abstract

Phospholipase A,, which is linked to a protein kinase C pathway, hydrolyzes phosphatidylcholine into cis-unsaturated free fatty acids and lysophosphatidylcholine (lysoPC). The present study investigated the effect of the free fatty acids, such as arachidonic, oleic, linoleic, and linolenic acid, and lysoPC on neurotransmission by monitoring population spikes (PSs) from the granular cell layer of rat hippocampal slices. All the free fatty acids and lysoPC examined here gradually increased PS amplitude to a different extent, the effect being evident 60 min after treatment. No significant synergistic enhancement in the PS amplitude was not induced by arachidonic acid following oleic acid, linoleic acid or lysoPC. The results of the present study, thus, demonstrate that phospholipase A(2)-linked free fatty acids and lysoPC are employed in the sustained facilitation of hippocampal neurotransmission, suggesting a significant role of a phospholipase A, signaling pathway in the neuroplasticity. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:33:48