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Titolo:
Expression of thyrotropin receptors in rat thymus
Autore:
Murakami, M; Hosoi, Y; Araki, O; Morimura, T; Imamura, M; Ogiwara, T; Mizuma, H; Mori, M;
Indirizzi:
Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 1, Maebashi, Gumma 3718511, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 25, volume: 68, anno: 2001,
pagine: 2781 - 2787
SICI:
0024-3205(20010511)68:25<2781:EOTRIR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; MYASTHENIA-GRAVIS; AUTOANTIBODIES; BEAR;
Keywords:
thymic epithelial cell; cyclic AMP; Graves' disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, M Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 Gumma 3718511, Japan
Citazione:
M. Murakami et al., "Expression of thyrotropin receptors in rat thymus", LIFE SCI, 68(25), 2001, pp. 2781-2787

Abstract

Thymic hyperplasia is associated with Graves' disease. It has been demonstrated that thyrotropin receptors are expressed in human thymus, and thymic thyrotropin receptors are suggested to be involved in the pathophysiology of Graves' disease. We have studied whether thyrotropin receptors are expressed in rat thymic tissue. Thyrotropin receptor mRNA was demonstrated in 5-day-old, 10-day-old, 20-day-old and adult rat thymus by reverse transcription polymerase chain reaction. Thyrotropin receptor mRNA was also demonstrated in cultured rat thymic epithelial cells. Thyrotropin stimulated cyclic AMP production in cultured rat thymic epithelial cells, suggesting l:he expression of functional thyrotropin receptors. The present results indicate that thyrotropin receptors are expressed in rat thymus. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:56:47