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Titolo:
Two-generation reproductive toxicity study of tributyltin chloride in female rats
Autore:
Ogata, R; Omura, M; Shimasaki, Y; Kubo, K; Oshima, Y; Aou, S; Inoue, N;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Hyg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Hyg, Fukuoka 8128582, Japan JST, CREST, Fukuoka, Japan JST Fukuoka JapanJST, CREST, Fukuoka, Japan Kyushu Univ, Grad Sch,Div Bioresource & Bioenvironm Sci, Dept Biosci & Biotechnol, Inst Marine Biol Chem,Lab Marine Environm Sci, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 ab Marine Environm Sci, Fukuoka 812, Japan Kyushu Univ, Grad Sch Med Sci, Dept Integrat Physiol, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 Dept Integrat Physiol, Fukuoka 812, Japan
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 2, volume: 63, anno: 2001,
pagine: 127 - 144
SICI:
1528-7394(20010525)63:2<127:TRTSOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE DEVELOPMENTAL TOXICITY; TRI-NORMAL-BUTYLTIN; SEXUAL-DIFFERENTIATION; PHENYLTIN COMPOUNDS; ESTROUS CYCLICITY; EXPOSURE; TESTOSTERONE; MORPHOLOGY; BEHAVIOR; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ogata, R Kyushu Univ, Grad Sch Med Sci, Dept Hyg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 t Hyg, Fukuoka 8128582, Japan
Citazione:
R. Ogata et al., "Two-generation reproductive toxicity study of tributyltin chloride in female rats", J TOX E H A, 63(2), 2001, pp. 127-144

Abstract

A two-generation reproductive toxicity study of the effects of tributyltinchloride (TBTCl) was conducted in female rats using dietary concentrationsof 5, 25, and 125 ppm TRTCl. Reproductive outcomes of darns (number and body weight of pups and the percentage or live pups) and the growth of femalepups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCl group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCl group. However, anincrease in anogenital distance was found in all TBTCl groups on postnatald 1. A dose-effect relationship was observed in TBTCl-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCl affects the sexual development and reproductive function of female rats. In addition, the TBTCl-induced increase in anogenital distance seems tosuggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCl used in this study are not environmentally relevant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:55:36