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Titolo:
Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats
Autore:
Tsukue, N; Toda, N; Tsubone, H; Sagai, M; Jin, WZ; Watanabe, G; Taya, K; Birumachi, J; Suzuki, AK;
Indirizzi:
Natl Inst Environm Studies, Air Pollutants Hlth Effects Res Team, Tsukuba,Ibaraki 3050053, Japan Natl Inst Environm Studies Tsukuba Ibaraki Japan 3050053 i 3050053, Japan Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo, Japan Univ Tokyo Tokyo Japan niv Tokyo, Grad Sch Agr & Life Sci, Tokyo, Japan Aomori Univ Hlth & Welf, Fac Hlth Sci, Aomori, Japan Aomori Univ Hlth & Welf Aomori Japan Welf, Fac Hlth Sci, Aomori, Japan Tokyo Univ Agr & Technol, Vet Physiol Lab, Tokyo 156, Japan Tokyo Univ Agr& Technol Tokyo Japan 156 t Physiol Lab, Tokyo 156, Japan
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 2, volume: 63, anno: 2001,
pagine: 115 - 126
SICI:
1528-7394(20010525)63:2<115:DE(ATR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; AIRWAY INFLAMMATION; PARTICULATE MATTER; ADJUVANT ACTIVITY; PARTICLES DEP; IGE ANTIBODY; MICE; TOXICITY; MUTAGENICITY; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, AK Natl Inst Environm Studies, Air Pollutants Hlth Effects Res Team, 16-2 Onogawa, Tsukuba, Ibaraki 3050053, Japan Natl Inst Environm Studies16-2 Onogawa Tsukuba Ibaraki Japan 3050053
Citazione:
N. Tsukue et al., "Diesel exhaust (DE) affects the regulation of testicular function in male Fischer 344 rats", J TOX E H A, 63(2), 2001, pp. 115-126

Abstract

To investigate the effects of diesel exhaust (DE) particles on the reproductive system, male Fischer 344 rats at 13 mo of age were exposed to clean air or DE at particle concentrations or 0.3, 1, or 3 mg/m(3) for 8 mo. DE did not markedly affect testicular and body weights. However, DE at 0.3 mg/m(3) significantly decreased prostate and coagulating gland weights, accompanied by a reduction in thymus and adrenal gland weight. In contrast there was a significant rise in the weights of prostate, seminal vesicles, and coagulating glands in the 3 mg/m(3) DE group. In rats exposed to 0.3 or 1 mg/m(3) DE, serum luteinizing hormone (LH) and testosterone increased significantly, while a rise in testicular testosterone was noted with 3 mg/m(3) DE. The concentrations of follicle-stimulating hormone (FSH) and inhibin as wellas the sperm head counts were not markedly altered in any treatment group. Positive staining with inhibin-a subunit and 3 beta -hydroxysteroid dehydrogenase (3 beta -HSD) were observed in Sertoli cells and Leydig cells, respectively. Immunolocalization of inhibin-alpha subunit and 3 beta -HSD was not changed by exposure to DE. In conclusion. DE appears to exert greater effects on accessory glands than on testes in Fischer 344 rats, and the responsiveness of rats is less than that found in mice.

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Documento generato il 19/01/20 alle ore 08:59:08