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Titolo:
Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0] octane derivative.
Autore:
Pecanha, EP; Fraga, CAM; Barreiro, EJ; Braga, MFM; Pereira, EFR; Albuquerque, EX;
Indirizzi:
Univ Fed Rio de Janeiro, Fac Farm, BR-21944970 Rio De Janeiro, Brazil UnivFed Rio de Janeiro Rio De Janeiro Brazil BR-21944970 BCeiro, Brazil Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Therapeut, Baltimore, MD 21201 USA Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Ciencias Biomed, Dept Farmacol Basica & Clin, BR-21944970 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21944970 BCeiro, Brazil
Titolo Testata:
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 408 - 412
SICI:
0103-5053(200105/06)12:3<408:SAPEOA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; SODIUM-BOROHYDRIDE; REDUCTION; NEBRACETAM; REGIONS; RATS;
Keywords:
2-azabicyclo[3.3.0]octane derivatives; diastereoselective reductive; amination/cyclization one-pot process; nebracetam analog;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Barreiro, EJ Univ Fed Rio de Janeiro, Fac Farm, CP 68006, BR-21944970 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro CP 68006 Rio De Janeiro Brazil BR-21944970 BC
Citazione:
E.P. Pecanha et al., "Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0] octane derivative.", J BRAZ CHEM, 12(3), 2001, pp. 408-412

Abstract

As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[ 3.3.0] octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:51:15