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Titolo:
Posterior fossa magnetic resonance imaging in autism
Autore:
Hardan, AY; Minshew, NJ; Harenski, K; Keshavan, MS;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 6, volume: 40, anno: 2001,
pagine: 666 - 672
SICI:
0890-8567(200106)40:6<666:PFMRII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM INVOLVEMENT; INFANTILE-AUTISM; CEREBELLAR VERMIS; CORPUS-CALLOSUM; HYPOPLASIA; SIZE; MRI; ABNORMALITY; ADULTS; VII;
Keywords:
cerebellum; vermis; brainstem; autism; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hardan, AY Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
A.Y. Hardan et al., "Posterior fossa magnetic resonance imaging in autism", J AM A CHIL, 40(6), 2001, pp. 666-672

Abstract

Objective: To determine whether the sizes and volumes of the posterior fossa structures are abnormal in non-mentally retarded autistic adolescents and adults. Method: Volume measurements of the cerebellum, vermis, and brainstem were obtained from coronal magnetic resonance imaging scans in 16 autistic subjects and 19 group-matched healthy controls. For the purpose of comparison with previous studies, area measurements of the midbrain, pens, medulla, total cerebellar vermis, and its three subregions were also obtained from a larger sample of 22 autistic males (mean age: 22.4 years; range: 12.2-51.8 years) and 22 individually matched controls (mean age 22.4 years; range: 12.9-52.2 years). Results: The total volume of the cerebellum and the cerebellar hemispheres were significantly larger in the autistic subjects with and without correcting for total brain volume. Volumes of the vermis andthe brainstem and all area measurements did not differ significantly between groups. Conclusions: There is an increase in the volume of the cerebellum in people with autism consistent with the increase in regional and total brain size reported in this developmental disorder. This finding is also concordant with evidence of cerebellar abnormalities from neuropathological and neuropsychological studies that point to the role of this structure, as part of a complex neural system, in the pathophysiology of autism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:48:17