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Titolo:
Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder
Autore:
King, BH; Wright, DM; Handen, BL; Sikich, I; Zimmerman, AW; McMahon, W; Cantwell, E; Davanzo, PA; Dourish, CT; Dykens, EM; Hooper, SR; Jaselskis, CA; Leventhal, BL; Levitt, J; Lord, C; Lubetsky, MJ; Myers, SM; Ozonoff, S; Shah, BG; Snape, M; Shernoff, EW; Williamson, K; Cook, EH;
Indirizzi:
Dartmouth Med Sch, Hanover, NH USA Dartmouth Med Sch Hanover NH USADartmouth Med Sch, Hanover, NH USA Vernalis Grp PLC, Winnersh, England Vernalis Grp PLC Winnersh EnglandVernalis Grp PLC, Winnersh, England Univ Calif Los Angeles, Neuropsychiat Inst, Los Angeles, CA 90024 USA UnivCalif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Sch Med, Pittsburgh, PA 15260 USA Univ N Carolina, Chapel Hill, NC 27515 USA Univ N Carolina Chapel Hill NCUSA 27515 olina, Chapel Hill, NC 27515 USA Kennedy Krieger Inst, Baltimore, MD USA Kennedy Krieger Inst Baltimore MDUSA dy Krieger Inst, Baltimore, MD USA Univ Utah, Salt Lake City, UT USA Univ Utah Salt Lake City UT USAUniv Utah, Salt Lake City, UT USA Univ Chicago, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637Univ Chicago, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 6, volume: 40, anno: 2001,
pagine: 658 - 665
SICI:
0890-8567(200106)40:6<658:DPSOAH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERVASIVE DEVELOPMENTAL DISORDERS; ABERRANT BEHAVIOR CHECKLIST; EXCITATORY AMINO-ACIDS; RETT-SYNDROME; SCHIZOPHRENIC CHILDREN; ADULTS; RECEPTORS; GLUTAMATE; BRAIN;
Keywords:
N-methyl-D-aspartate (NMDA); hyperactivity; irritability; placebo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: King, BH Dartmouth Coll, Hitchcock Med Ctr, Dept Psychiat, 1 Med Ctr Dr, Lebanon, NH 03756 USA Dartmouth Coll 1 Med Ctr Dr Lebanon NH USA 03756 on, NH 03756 USA
Citazione:
B.H. King et al., "Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder", J AM A CHIL, 40(6), 2001, pp. 658-665

Abstract

Objective: To test the hypothesis that amantadine hydrochloride is a safe and effective treatment for behavioral disturbances-for example, hyperactivity and irritability-in children with autism. Method: Thirty-nine subjects (intent to treat; 5-19 years old; IQ > 35) had autism diagnosed according to DSM-IV and ICD-10 criteria using the Autism Diagnostic Interview-Revised and the Autism Diagnostic Observation Schedule-Generic. The Aberrant Behavior Checklist-Community Version (ABC-CV) and Clinical Global Impressions (CGI) scale were used as outcome variables. After a 1-week, single-blind placebo run-in, patients received a single daily dose of amantadine (2.5 mg/kg per day) or placebo for the next week, and then bid dosing (5.0 mg/kg per day) for the subsequent 3 weeks. Results: When assessed on the basis of parent-rated ABC-CV ratings of irritability and hyperactivity, the mean placebo response rate was 37% versus amantadine at 47% (not significant). However, in the amantadine-treated group there were statistically significant improvements in absolute changes in clinician-rated ABC-CVs for hyperactivity (amantadine -6.4 versus placebo -2.1; p =.046) and inappropriate speech (-1.9 versus 0.4; p =.008). CGI scale ratings were higher in the amantadine group: 53% improved versus 25% (p =.076). Amantadine was well tolerated. Conclusions: Parents did not report statistically significant behavioral change with amantadine. However, clinician-rated improvements in behavioral ratings following treatment with amantadine suggest that further studies with this or other drugs acting on the glutamatergic system are warranted. The designof these and similar drug trials in children with autistic disorder must take into account the possibility of a large placebo response.

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Documento generato il 19/01/20 alle ore 11:41:49