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Titolo:
Cyclosporin A treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing
Autore:
Rabchevsky, AG; Fugaccia, I; Sullivan, PG; Scheff, SW;
Indirizzi:
Univ Kentucky, Sanders Brown Ctr Aging 233, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 r Aging 233, Lexington, KY 40536 USA
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 5, volume: 18, anno: 2001,
pagine: 513 - 522
SICI:
0897-7151(200105)18:5<513:CATFSC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; AXONAL DAMAGE; CONTUSION; ISCHEMIA; BARRIER; MITOCHONDRIAL; RECOVERY; PERMEABILITY; AMELIORATION; HOMEOSTASIS;
Keywords:
immunosuppression; lesion volume; stereology; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Scheff, SW Univ Kentucky, Sanders Brown Ctr Aging 233, Lexington, KY 40536USA Univ Kentucky Lexington KY USA 40536 , Lexington, KY 40536 USA
Citazione:
A.G. Rabchevsky et al., "Cyclosporin A treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing", J NEUROTRAU, 18(5), 2001, pp. 513-522

Abstract

The immunosuppressant drug cyclosporin A (CsA) has significant neuroprotective properties following CNS injury. In the present study, we assessed theefficacy of CsA therapy following a moderate spinal cord injury (SCI), Adult female rats were injured with the NYU impactor from a height of 12.5 mm,and CsA or vehicle therapy was initiated 15 min after the injury. All animals were behaviorally tested with the BBB locomotor rating scale prior to morphological assessment of changes in the spinal cord. CsA therapy failed to significantly improve the behavioral recovery following the injury. Usinga unique stereological approach to assess tissue damage, it was determinedthat CsA did not alter the amount of spared tissue. The possible neuroprotective effects of CsA, observed in other models of CNS injury, do not appear to influence SCI pathology, perhaps reflecting both anatomical and physiological differences between these distinct regions of the CNS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:51:55