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Titolo:
S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury
Autore:
Pleines, UE; Morganti-Kossmann, MC; Rancan, M; Joller, H; Trentz, O; Kossmann, T;
Indirizzi:
Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Div Res, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Med, Div Clin Immunol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 5, volume: 18, anno: 2001,
pagine: 491 - 498
SICI:
0897-7151(200105)18:5<491:SBRTEO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; CEREBROSPINAL-FLUID; COMPUTED-TOMOGRAPHY; TNF-ALPHA; SERUM; PROTEIN; ADHESION; CALCIUM; DAMAGE; CELLS;
Keywords:
IL-6; inflammation; NSE; s-100 beta; sICAM-1; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kossmann, T Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich,Switzerland Univ Zurich Hosp Ramistr 100 Zurich Switzerland CH-8091 rland
Citazione:
U.E. Pleines et al., "S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury", J NEUROTRAU, 18(5), 2001, pp. 491-498

Abstract

It has been hypothesized that immunoactivation may contribute to brain damage and affect outcome after traumatic brain injury (TBI). In order to determine the role of inflammation after TBI, we studied the interrelationship of the immune mediators sICAM-1 and IL-6 with the levels of S-100 beta and neuronal specific enolase (NSE), both recognized markers of brain damage. In addition, the extent and type of cerebral injury and the neurological outcome were related to these measured markers of injury. An evident elevationof S-100 beta (range of means: 2.7-81.4 ng/mL) and NSE (range of means: 2.0-81.3 ng/mL) was observed in CSF of all 13 patients during the first 3 posttraumatic days and decreased over 2 weeks. In parallel, the production of sICAM-1 (range of means: 0.7-11.9 ng/mL) and IL-6 (range of means: 0.1-8.2 ng/mL) was also markedly enhanced in CSF. The CSF means of S-100 beta and NSE per patient correlated with IL-6 (r = 0.60, p < 0.05; and r = 0.64, p < 0.05, respectively), whereas the corresponding means in serum showed a significant correlation only between NSE and IL-6 (r = 0.56, p < 0.05), MaximalCSF values of NSE and sICAM-1 Correlated with each other (r = 0.57, p < 0.05). The contusion sizes assessed on the CT scans correlated with the meansof S-100 beta (r = 0.63, p < 0.05) and NSE (r = 0.71,p < 0.05) in CSF and with the mean of S-100 beta in serum, although not statistically significant (r = 0.52, p = 0.06), hut not with serum NSE, Interestingly, linear regression analysis demonstrated that means of S-100 beta in CSF (r = 0.78, p = 0.002) and serum (r = 0.82, p < 0.001) correlated with the GOS, These results indicate that the elevation of these parameters in CSF depends on the extent of injury and that S-100<beta> may be a predictor of outcome after TBI, whereas NSE reflects better the inflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:19:15