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Titolo:
Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf21
Autore:
Lazzaro, MA; Picketts, DJ;
Indirizzi:
Univ Ottawa, Dept Med, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Dept Med, Ottawa, ON K1N 6N5, Canada Ottawa Hosp, Res Inst, Ottawa, ON, Canada Ottawa Hosp Ottawa ON CanadaOttawa Hosp, Res Inst, Ottawa, ON, Canada Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Immunol, Ottawa, ON K1N 6N5, Canada
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 77, anno: 2001,
pagine: 1145 - 1156
SICI:
0022-3042(200105)77:4<1145:CACOTM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATIN-REMODELING FACTORS; LINKED MENTAL-RETARDATION; ATR-X SYNDROME; DNA-BINDING DOMAIN; SACCHAROMYCES-CEREVISIAE; PROGESTERONE-RECEPTOR; RETT-SYNDROME; IN-VITRO; MUTATION; FAMILY;
Keywords:
chromatin remodeling; developmental expression; ISWI; Snf2h; Snf21; XLMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Picketts, DJ Univ Ottawa, Dept Med, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 awa, ON K1N 6N5, Canada
Citazione:
M.A. Lazzaro e D.J. Picketts, "Cloning and characterization of the murine Imitation Switch (ISWI) genes: differential expression patterns suggest distinct developmental roles for Snf2h and Snf21", J NEUROCHEM, 77(4), 2001, pp. 1145-1156

Abstract

Here we report the cloning of two cDNAs, Snf2h and Snf2l, encoding the murine members of the imitation Switch (ISWI) family of chromatin remodeling proteins. To gain insight into their function we examined the spatial and temporal expression patterns of Snf2h and Snf2l during development. In the brain, Snf2h is prevalent in proliferating cell populations whereas. Snf2l ispredominantly expressed in terminally differentiated neurons after birth and in adult animals, concomitant with the expression of a neural specific isoform. Moreover, a similar proliferation/differentiation relationship of expression for these two genes was observed in the ovaries and testes of adult mice. These results are consistent with a role of Snf2h complexes in replication-associated nucleosome assembly and suggest that Snf2l complexes have distinct functions associated with cell maturation or differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:20:36