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Titolo:
Overcoming of radioresistance in human gliomas by p21(WAF1/CIP1) antisenseoligonucleotide
Autore:
Kokunai, T; Urui, S; Tomita, H; Tamaki, N;
Indirizzi:
Kakogawa Municipal Hosp, Dept Neurosurg, Kakogawa, Hyogo, Japan Kakogawa Municipal Hosp Kakogawa Hyogo Japan urg, Kakogawa, Hyogo, Japan Kobe Univ, Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 Neurosurg, Chuo Ku, Kobe, Hyogo 650, Japan
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 2, volume: 51, anno: 2001,
pagine: 111 - 119
SICI:
0167-594X(200101)51:2<111:OORIHG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLIOBLASTOMA CELLS; TUMOR SUPPRESSION; ANTICANCER AGENTS; DOWN-REGULATION; P53; EXPRESSION; GENE; INHIBITION; APOPTOSIS; PROTEIN;
Keywords:
p21; radiosensitivity; glioma; apoptosis; antisense oligonucleotide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kokunai, T Kakogawa Municipal Hosp, Dept Neurosurg, 384-1 Hiratsu Yoneda Cho, Kakogawa, Hyogo, Japan Kakogawa Municipal Hosp 384-1 Hiratsu Yoneda ChoKakogawa Hyogo Japan
Citazione:
T. Kokunai et al., "Overcoming of radioresistance in human gliomas by p21(WAF1/CIP1) antisenseoligonucleotide", J NEURO-ONC, 51(2), 2001, pp. 111-119

Abstract

Malignant gliomas are highly resistant tumors against gamma -irradiation and contained overexpression of p21(WAF1/CIP1) (p21). Overexpression of p21 enhanced clonogenic survival and suppressed apoptosis after gamma -irradiation in human brain tumor cell lines with or without p53 protein deficiency. The effect of antisense oligonucleotide to p21 against the gamma -irradiation-induced apoptosis and cytotoxicity in malignant glioma cell lines was examined. Antennapedia homeodomain internalization peptide was used as an insertion vector. The high transfection efficiency of Antennapedia homeodomain internalization peptide joined with antisense oligonucleotide was observed. The pretreatment with antisense oligonucleotide enhanced the gamma -irradiation-induced apoptosis and cytotoxicity in radioresistant glioma cells. p21 may represent an important new target for radiosensitization protocols,possibly involving antisense oligonucleotide directed against p21.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:31:33