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Titolo:
Correlating rates of cerebral atrophy in Parkinson's disease with measuresof cognitive decline
Autore:
Hu, MTM; White, SJ; Chaudhuri, KR; Morris, RG; Bydder, GM; Brooks, DJ;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England Hammersmith Hosp London England W12 0NN lin Sci, London W12 0NN, England Hammersmith Hosp, Imperial Coll Sch Med, Div Neurosci, London W12 0NN, England Hammersmith Hosp London England W12 0NN eurosci, London W12 0NN, England Hammersmith Hosp, Imperial Coll Sch Med, Robert Steiner MR Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN MR Unit, London W12 0NN, England Guys Kings & St Thomas Sch Med, Dept Neurol, Movement Disorders Unit, InstNeurol, London, England Guys Kings & St Thomas Sch Med London England stNeurol, London, England Univ London Kings Coll, Inst Psychiat, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Univ Hosp Lewisham, Lewisham, England Univ Hosp Lewisham Lewisham England iv Hosp Lewisham, Lewisham, England Univ London Kings Coll, Kings Neurosci Ctr, Dept Clin Neuropsychol, LondonWC2R 2LS, England Univ London Kings Coll London England WC2R 2LS , LondonWC2R 2LS, England Univ London Kings Coll, Inst Psychiat, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 5, volume: 108, anno: 2001,
pagine: 571 - 580
SICI:
0300-9564(2001)108:5<571:CROCAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT READING TEST; ALZHEIMERS-DISEASE; NORMATIVE DATA; LEWY BODIES; DEMENTIA; DIAGNOSIS; ACCURACY; BRAIN; QUANTIFICATION; VALIDATION;
Keywords:
atrophy; Parkinson's disease; cognitive;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, MTM Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN 2 0NN, England
Citazione:
M.T.M. Hu et al., "Correlating rates of cerebral atrophy in Parkinson's disease with measuresof cognitive decline", J NEURAL TR, 108(5), 2001, pp. 571-580

Abstract

We studied eight clinically non-demented PD patients and ten age-matched controls with serial volumetric T-1-weighted MRI. All PD patients underwent full neuropsychological testing at baseline and follow up scans. Sub-voxel coregistration of the serial MRI scans with quantification of changes in total brain substance and ventricular size per year was performed. The PD patients had significant reductions in both percentage and absolute annual brain volume loss when compared to age-matched controls (p ( 0.001). There were significant correlations between reductions in percentage brain volume loss and estimated reductions in performance IQ (r = 0.841, p = 0.004) and full scale IQ (r = 0.63, p = 0.049), measured by subtracting IQ measures at time of follow up scan from premorbid estimates. In conclusion, PD patients have a significant rate of median brain volume loss [10.35 (range) 6.69-16.90ml/year] with no significant loss seen in age-matched controls, and thesechanges correlate with global measures of cognitive decline. Further longitudinal studies could evaluate whether serial volumetric MRI is a useful technique in predicting the preclinical onset of dementia in Parkinson's disease patients, and its role in the assessment of putative treatments for slowing disease progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:48:01