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Titolo:
Brain glycine levels in triazolam-treated albino rats
Autore:
Aburawi, SM; Ahmed, SS; Elhwuegi, AS; Saad, SF; Attia, AS;
Indirizzi:
Great Alfateh Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tripoli, Libya Great Alfateh Univ Med Sci Tripoli Libya acol & Toxicol, Tripoli, Libya Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt Cairo Univ Cairo Egypt ac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 5, volume: 108, anno: 2001,
pagine: 527 - 539
SICI:
0300-9564(2001)108:5<527:BGLITA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; PERFORMANCE LIQUID-CHROMATOGRAPHY; D-ASPARTATE RECEPTOR; BENZODIAZEPINE RECEPTORS; GABA; DIAZEPAM; CHANNELS; NEURONS; COMPLEX; DERIVATIVES;
Keywords:
albino rats; drug abuse; glycine; HPLC; tolerance; triazolam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Aburawi, SM POB 84593, Tripoli, Libya POB 84593 Tripoli LibyaPOB 84593, Tripoli, Libya
Citazione:
S.M. Aburawi et al., "Brain glycine levels in triazolam-treated albino rats", J NEURAL TR, 108(5), 2001, pp. 527-539

Abstract

The present study investigates the effects of acute and chronic administration of triazolam in albino rats on glycine levels in different brain areas. Three experiments were conducted. In the first, five groups of rats were acutely treated with different doses of triazolam (0.25 mg/kg-4.0mg/kg i.p.). In the second experiment, rats were treated chronically by a single daily dose of triazolam (started by 0.25 mg/kg and increased by time to 1.0mg/kg) for 5 weeks, simulating clinical use. In the third, rats were treated chronically three daily doses of triazolam (started by 0.25mg/kg and increased by time to 0.5 mg/kg) for 20 days, simulating a form of drug abuse. Brainlevels of glycine and plasma levels of triazolam were measured using HPLC technique. The acute triazolam administration produced an increase in glycine levels in almost all brain areas studied. The chronic administration of single daily dose of triazolam produced normal glycine levels in most of the brain areas; this indicates the development of tolerance to glycine content increasing action of triazolam. The chronic administration of three daily doses of triazolam produced a decrease in glycine levels in almost all brain regions studied, which might be a prerequisite for oncoming withdrawal syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:23:13