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Titolo:
Interleukin-18 expression induced by Epstein-Barr virus-infected cells
Autore:
Yao, L; Setsuda, J; Sgadari, C; Cherney, B; Tosato, G;
Indirizzi:
NCI, Dept Transplantat Immunol, Med Branch, DCS,NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 ol, Med Branch, DCS,NIH, Bethesda, MD 20892 USA US FDA, Ctr Biol Evaluat & Res, Div Therapeut Prot, Bethesda, MD USA US FDA Bethesda MD USA aluat & Res, Div Therapeut Prot, Bethesda, MD USA Ist Super Sanita, Virol Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 nita, Virol Lab, I-00161 Rome, Italy
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 5, volume: 69, anno: 2001,
pagine: 779 - 784
SICI:
0741-5400(200105)69:5<779:IEIBEV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-GAMMA PRODUCTION; NECROSIS IN-VIVO; INTERFERON-GAMMA; B-CELLS; T-CELLS; LYMPHOPROLIFERATIVE DISEASE; INDUCIBLE PROTEIN-10; CYTOKINE PRODUCTION; TUMOR-REGRESSION; CXC CHEMOKINES;
Keywords:
Burkitt lymphoma; interferon gamma; angiogenesis; latent membrane protein-1; tumor regression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Yao, L NCI, Dept Transplantat Immunol, Med Branch, DCS,NIH, Bldg 10,Room 12C07, Bethesda, MD 20892 USA NCI Bldg 10,Room 12C07 Bethesda MD USA 20892 Bethesda, MD 20892 USA
Citazione:
L. Yao et al., "Interleukin-18 expression induced by Epstein-Barr virus-infected cells", J LEUK BIOL, 69(5), 2001, pp. 779-784

Abstract

Human Epstein-Barr virus (EBV)-negative Burkitt lymphomas cells usually grow as malignant subcutaneous tumors in athymic mice, but these tumors regress when the Burkitt cells are injected in conjunction with EBV-positive lymphoblastoid cells or when the Burkitt cells are transfected with the EBV latent membrane protein-1 (LMP-I) gene. Tumor regression is mediated, in part, by murine interferon gamma (IFN-y) and the IFN-gamma -induced murine chemokine IFN-gamma -inducible protein-10 (IP-10), The mechanisms by which EBV-LIMP-1 promotes the expression of IFN-y has remained unclear. Here we show that murine interleukin (IL)-18 was consistently expressed in regressing Burkitt tumors but was either expressed at low levels or absent from progressively growing Burkitt tumors. By immunohistochemical methods, IL-18 proteinwas visualized in regressing but not in progressively growing Burkitt tumors, In contrast, IL-12 p35 and IL-12 p40 were only rarely expressed in regressing Burkitt tumors. In splenocyte cultures, EBV-infected lymphoblastoid cells and LMP-1-transfected Burkitt cells promoted the expression of IL-18 but not the expression of IL-12 p35 and IL-12 p40. A neutralizing antibody directed at murine IL-18 reduced murine IP-10 expression induced by EBV-immortalized cells in splenocyte cultures. These results pro,ide evidence for IL-18 expression in response to a viral latency protein and suggest that IL-18 may play an important role as an endogenous inducer of IFN-gamma expression, thereby contributing to tumor regression.

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Documento generato il 15/07/20 alle ore 08:18:19