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Titolo:
Treatment of acute myeloblastic leukaemia in a patient with Bombay blood type: a case report
Autore:
Okamoto, Y; Tsuda, T; Matsunami, M; Hirose, T; Sakaguchi, R; Katayama, N; Ota, K;
Indirizzi:
Wakayama Med Coll, Dept Blood Transfus Med & Clin Hematol, Wakayama 6410012, Japan Wakayama Med Coll Wakayama Japan 6410012 ematol, Wakayama 6410012, Japan
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 2, volume: 29, anno: 2001,
pagine: 140 - 146
SICI:
0300-0605(200103/04)29:2<140:TOAMLI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; POINT MUTATIONS; INDIVIDUALS; PHENOTYPE; DELETION; INDUCTION; GENE; FUT2;
Keywords:
Bombay blood type (Oh); frozen red cells; acute myeloblastic leukaemia (AML-M1); Cryptococcus pneumonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Okamoto, Y Wakayama Med Coll, Dept Blood Transfus Med & Clin Hematol, 811-1 Kimiidera, Wakayama 6410012, Japan Wakayama Med Coll 811-1 Kimiidera Wakayama Japan 6410012 Japan
Citazione:
Y. Okamoto et al., "Treatment of acute myeloblastic leukaemia in a patient with Bombay blood type: a case report", J INT MED R, 29(2), 2001, pp. 140-146

Abstract

A 62-year-old female was admitted to our hospital with suspected acute leukaemia and after investigation we diagnosed acute myeloblastic leukaemia (AML-M1). The patient's blood type was found to be the very rare Bombay type and surveillance of her relatives showed the same blood type in her male cousin on her mother's side. Alongside chemotherapy the patient received 4000ml of frozen Bombay-type red cells, 1400 ml of concentrated red cells in manitol adenine phosphate solutions and 360 units of type O concentrated platelets without marked effects. The anti-H antibody was initially at 128 dilution but for unknown reasons increased to 2048 dilution after remission ofAML-M1. About 3 months after hospitalization the patient died of Cryptococcus neoformans pneumonia despite strict precautions against infection. Although AML-M1 is a common adult leukaemia and is chemosensitive to anti-leukaemic drugs, neither AML-M1 in a patient with Bombay-type red cells nor its treatment with chemotherapy and transfusion with type Oh frozen red cells have previously been reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:23:22