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Titolo:
Combined effects of heart rate and pulse pressure on cardiovascular mortality according to age
Autore:
Thomas, F; Bean, K; Provost, JC; Guize, L; Benetos, A;
Indirizzi:
Ctr Invest Prevent & Clin, F-75016 Paris, France Ctr Invest Prevent & Clin Paris France F-75016 in, F-75016 Paris, France INSERM, U258, Paris, France INSERM Paris FranceINSERM, U258, Paris, France
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 5, volume: 19, anno: 2001,
pagine: 863 - 869
SICI:
0263-6352(200105)19:5<863:CEOHRA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS; POPULATION; PREDICTOR; RISK;
Keywords:
cardiovascular mortality; pulse pressure; heart rate; gender; age;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Benetos, A Ctr Invest Prevent & Clin, 6-14 Rue Perouse, F-75016 Paris, France Ctr Invest Prevent & Clin 6-14 Rue Perouse Paris France F-75016
Citazione:
F. Thomas et al., "Combined effects of heart rate and pulse pressure on cardiovascular mortality according to age", J HYPERTENS, 19(5), 2001, pp. 863-869

Abstract

Objectives The aim of the study was to assess the combined effects of pulse pressure (PP) and heart rate (HR) on cardiovascular mortality in a large French population, Design The study population was composed of 125 513 men and 96 301 women aged 16-95 years who had a health check-up at the IPC Center between January 1978 and December 1988. Subjects taking antihypertensivetreatment were excluded, Mortality was assessed for an 8-year period. HR and PP were classified into three groups. HR groups were: < 60, 60-79 and <greater than or equal to> 80 beats per minute (bpm), PP groups were: < 58, 50-64 and <greater than or equal to> 65 mmHg, Results In men, PP and HR wereboth positively associated with cardiovascular mortality risk, In women, mean arterial pressure (MAP) but not PP or HR was associated with cardiovascular mortality. In men, a combined elevation of PP and HR was associated with an important increase of cardiovascular mortality risk, The group with the highest PP and the highest HR had a 4.8-fold increase in cardiovascular mortality risk as compared to the reference group (PP < 50 mmHg and HR < 60bpm), This effect was more pronounced in younger men (5.4-fold increase) than in older men (3.7-fold increase), as compared to the reference groups of the same age. In Conclusion A combined elevation of the two components ofpulsatile arterial stress is associated with an important increase in cardiovascular mortality in men, especially in younger men. In women, steady-state stress (evaluated primarily by MAP), but not pulsatile stress, is an important determinant of cardiovascular mortality. J Hypertens 19:863-869 (C)2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:15:52