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Titolo:
Frequent loss of heterozygosity at 3p25-p26 is associated with invasive oral squamous cell carcinoma
Autore:
Kayahara, H; Yamagata, H; Tanioka, H; Miki, T; Hamakawa, H;
Indirizzi:
Ehime Univ, Sch Med, Dept Oral & Maxillofacial Surg, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan Ehime Univ Matsuyama Ehime Japan 790 atr Med, Matsuyama, Ehime 790, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 46, anno: 2001,
pagine: 335 - 341
SICI:
1434-5161(2001)46:6<335:FLOHA3>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; CHROMOSOME 3P; ALLELIC LOSS; MICROSATELLITE INSTABILITY; POOR SURVIVAL; SHORT ARM; CANCER; HEAD; NECK; CARCINOGENESIS;
Keywords:
loss of heterozygosity; microsatellite instability; oral squamous cell carcinoma; oral epithelial dysplastic lesion; chromosome 3p;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kayahara, H Ehime Univ, Sch Med, Dept Oral & Maxillofacial Surg, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
H. Kayahara et al., "Frequent loss of heterozygosity at 3p25-p26 is associated with invasive oral squamous cell carcinoma", J HUM GENET, 46(6), 2001, pp. 335-341

Abstract

Recent molecular evidence suggests that allelic deletions of chromosomes are involved in the carcinogenesis of various neoplasms, including oral squamous cell carcinoma (OSCC). To determine the role of 3p deletions in Japanese OSCC and to define the localization of putative tumor suppressor genes, we initially examined loss of heterozygosity (LOH), using nine microsatellite markers in 36 OSCCs and 28 oral epithelial dysplastic lesions (OEDLs). LOH on chromosome 3p was observed at one or more loci in 72% of OSCCs and 18% of OEDLs. Fourteen (61%) of 23 OSCC patients informative at D3S2450 (3pter-p24.2) showed LOH most frequently, in contrast to OEDL, where LOH was never seen at this locus. Interestingly, we found a significant association between an allelic deletion at this locus and the histologic grade of mode oftumor invasion. Therefore, we also examined allelic deletion on chromosome3p telomeric to where D3S2450 was located. A common deletion region was identified between D352450 and D3S3591, Our results provide evidence for the presence of a tumor suppressor gene in a 0.8-cM region bordered by D352450 and D3S3591 at 3p25-p26, which may play a role in carcinogenesis and invasion of OSCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:46:10