Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Development of genetic hypotheses in essential hypertension
Autore:
Lalouel, JM; Rohrwasser, A;
Indirizzi:
Univ Utah, Eccles Inst Human Genet, Dept Human Genet, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Genet, Salt Lake City, UT 84112 USA
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 46, anno: 2001,
pagine: 299 - 306
SICI:
1434-5161(2001)46:6<299:DOGHIE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBUNIT 825T ALLELE; BLOOD-PRESSURE VARIATION; ANGIOTENSINOGEN GENE; MOLECULAR-GENETICS; IMMORTALIZED LYMPHOBLASTS; SODIUM REDUCTION; POINT MUTATIONS; ALPHA-ADDUCIN; MESSENGER-RNA; MILAN STRAIN;
Keywords:
essential hypertension; genetics; mechanism of disease; adducin; G protein beta 3 subunit; angiotensinogen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Lalouel, JM Univ Utah, Eccles Inst Human Genet, Dept Human Genet, 15 North2030 East,Room 6200, Salt Lake City, UT 84112 USA Univ Utah 15 North 2030 East,Room 6200 Salt Lake City UT USA 84112
Citazione:
J.M. Lalouel e A. Rohrwasser, "Development of genetic hypotheses in essential hypertension", J HUM GENET, 46(6), 2001, pp. 299-306

Abstract

Essential hypertension illustrates the formidable task presented by the identification of genetic determinants of common disease. Making an initial genetic inference may prove difficult enough; the subsequent demonstration of functional significance at various levels of biological integration may be even more challenging. We review three instances in which an initial genetic inference has led to the development of testable hypotheses pursued at increasingly higher levels of biological organization. These include the adducin, the G protein beta3 subunit, and the angiotensinogen hypotheses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:29:19