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Titolo:
Seroepidemiological study of hepatitis E virus infection in Japan using a newly developed antibody assay
Autore:
Tanaka, E; Takeda, N; Li, TC; Orii, K; Ichijo, T; Matsumoto, A; Yoshizawa, K; Iijima, T; Takayama, T; Miyamura, T; Kiyosawa, K;
Indirizzi:
Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY
fascicolo: 5, volume: 36, anno: 2001,
pagine: 317 - 321
SICI:
0944-1174(200105)36:5<317:SSOHEV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B HEPATITIS; EPIDEMIC NON-A; LINKED-IMMUNOSORBENT-ASSAY; TRANSMISSION; PAKISTAN; HEV;
Keywords:
hepatitis E virus; seroepidemiology; hepatitis E virus antibody assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, E Shinshu Univ, Sch Med, Dept Internal Med 2, 3-1-1 Asahi, Matsumoto, Nagano3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 1, Japan
Citazione:
E. Tanaka et al., "Seroepidemiological study of hepatitis E virus infection in Japan using a newly developed antibody assay", J GASTRO, 36(5), 2001, pp. 317-321

Abstract

Purpose. A seroepidemiological study of hepatitis E virus (HEV) infection was conducted in Japan, where HEV infection is not considered endemic. Methods. IgG and IgM class antibodies to HEV were measured with a newly developed enzyme-linked immunosorbent assay in which recombinant virus-like particles were used as an antigen. A total of 1253 individuals (401 males and 852females; age range, 6-89 years) were enrolled from two different areas: area 1 (n = 478), in which hepatitis C was endemic: and area 2 (n = 775), in which it was not endemic. Results. The HEV antibody (IgG class) positive rate was 6.7% in area 1 and 4.6% in area 2. Similarly, the HAV antibody (Ige class) positive rates were 65.3% and 72.3%. The age- and sex-specific prevalence of both HAV and HEV antibodies was quite similar in the two areas, and the HAV antibody positive rate clearly increased with age in both males and females. On the other hand, the HEV antibody positive rate showed a slight tendency to increase with age in males, but not in females. None of the 32 individuals with the HEV antibody who were interviewed had a history of visiting countries in which hepatitis E was endemic. In both areas, the mean age, percentage of males, and HAV antibody positive rate were significantly higher in the group of individuals with the HEV antibody than in the group of those without it, according to conventional statistical analyses. Of the three factors age, male sex, presence of HAV antibody, and the area factor, only male sex was statistically significant (P < 0.001) on multivariate logistic regression analysis. Two (0.2%) of the total of 1253 individualswere positive for the IgM class antibody to HEV. Conclusions. Our results suggest the possibility that HEV infection is circulating in Japan at a lowlevel, HEV infection was associated with male sex, but not with HAV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:36:16