Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of the melanin-concentrating hormone (MCH) receptor mRNA in therat brain
Autore:
Saito, Y; Cheng, M; Leslie, FM; Civelli, O;
Indirizzi:
Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif IrvineIrvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 v & Cell Biol, Irvine, CA 92697 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 435, anno: 2001,
pagine: 26 - 40
SICI:
0021-9967(20010618)435:1<26:EOTMH(>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; PROTEIN-COUPLED RECEPTOR; NUCLEUS-ACCUMBENS SHELL; CENTRAL-NERVOUS-SYSTEM; FEEDING-BEHAVIOR; MESSENGER-RNA; BODY-WEIGHT; FEMALE RAT; ALPHA-MSH; CONNECTIONS;
Keywords:
neuropeptide; G protein-coupled receptor; in situ hybridization; olfactory learning; appetite;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Civelli, O Univ Calif Irvine, Dept Pharmacol, 369 MedSurge 2, Irvine, CA 92697 USA Univ Calif Irvine 369 MedSurge 2 Irvine CA USA 92697 92697 USA
Citazione:
Y. Saito et al., "Expression of the melanin-concentrating hormone (MCH) receptor mRNA in therat brain", J COMP NEUR, 435(1), 2001, pp. 26-40

Abstract

The melanin-concentrating hormone (MCH) system is thought to be an important regulator of food intake. Recently the orphan G protein-coupled receptorSLC-1 was identified as the MCH receptor (MCHR). Preliminary analyses of MCHR mRNA distribution have supported a role for the MCH system in nutritional homeostasis. We report here a complete anatomical distribution of the MCHR mRNA. We have found high levels of expression of MCHR mRNA in most anatomical areas implicated in control of olfaction, with the exception of the main olfactory bulb. Dense labeling was also detected in the hippocampal formation, subiculum, and basolateral amygdala, all of which are important in learning and memory, and in the shell of the nucleus accumbens, a substratefor motivated behavior and feeding. Within the hypothalamus, MCHR mRNA wasmoderately expressed in the ventromedial nucleus, arcuate nucleus, and zona incerta, all of which serve key roles in the neuronal circuitry of feeding. In the brainstem, strong expression was observed in the locus coeruleus,which is implicated in arousal, as well as in nuclei that contribute to orofacial function and mastication, including the facial, hypoglossal, motor trigeminal, and dorsal motor vagus nuclei. In most regions there was a goodcorrespondence between MCHR mRNA distribution and that of MCH-immunoreactive fibers. Taken together, these data suggest that MCH may act at various levels of the brain to integrate various aspects of feeding behavior. However, the extensive MCHR distribution throughout the brain suggests that this receptor may play a role in other functions, most notably reinforcement, arousal, sensorimotor integration, and autonomic control. a zool Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:40:17